Roux-en-Y胃旁路术后人体皮下脂肪组织中的脂肪细胞大小和瘦素受体表达
Adipocyte Size and Leptin Receptor Expression in Human Subcutaneous Adipose Tissue After Roux-en-Y Gastric Bypass.
作者信息
Tamez Martha, Ramos-Barragan Victoria, Mendoza-Lorenzo Patricia, Arrieta-Joffe Pablo, López-Martínez Sergio, Rojano-Rodríguez Martín E, Moreno-Portillo Mucio, Frigolet María E
机构信息
Clínica de Obesidad y Cirugía Bariátrica, Hospital General "Dr. Manuel Gea González", Mexico City, Mexico.
Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, Mexico.
出版信息
Obes Surg. 2017 Dec;27(12):3330-3332. doi: 10.1007/s11695-017-2930-0.
The molecular mechanisms implicated in pronounced weight loss and metabolic benefits after bariatric surgery are still unknown. Adipocyte phenotype and metabolism have not been entirely explored. However, some features of adipocyte function have been studied, such as adipocyte size and inflammation, which are both reduced after bariatric surgery. Adipocyte fat metabolism, which is partly regulated by leptin, is likely modified, since adipocyte area is decreased. Here, we show that leptin receptor expression is increased, while adipocyte size is decreased 8 months after Roux-en-Y gastric bypass. Thus, adipocyte function is possibly modified by improved leptin signaling after bariatric surgery.
减肥手术后显著体重减轻和代谢益处所涉及的分子机制仍不清楚。脂肪细胞的表型和代谢尚未得到充分研究。然而，已经对脂肪细胞功能的一些特征进行了研究，如脂肪细胞大小和炎症，减肥手术后这些特征都会降低。由于脂肪细胞面积减小，部分受瘦素调节的脂肪细胞脂肪代谢可能发生改变。在此，我们表明，Roux-en-Y胃旁路术后8个月，瘦素受体表达增加，而脂肪细胞大小减小。因此，减肥手术后瘦素信号的改善可能会改变脂肪细胞功能。
Zotero 插件