Ray Amitabha
Lake Erie College of Osteopathic Medicine, Seton Hill University, Greensburg, PA 15601, United State.
World J Clin Cases. 2018 Oct 26;6(12):483-492. doi: 10.12998/wjcc.v6.i12.483.
Obesity is an important risk factor for postmenopausal breast cancer and also a poor prognostic factor among cancer patients. Moreover, obesity is associated with a number of health disorders such as insulin resistance/type-2 diabetes mellitus, hypertension, and other cardiovascular diseases. Frequently, these health disorders exhibit as components/complications of the metabolic syndrome. Nevertheless, obesity-related diseases may coexist with postmenopausal breast cancer; and these comorbid conditions could be substantial. Therefore, it may be assumed that different diseases including breast cancer could originate from a common pathological background in excessive adipose tissue. Adipocyte-released hormone-like cytokine (or adipokine) leptin behaves differently in a normal healthy state and obesity. A growing body of evidence suggests an important role of leptin in our major obesity-related health issues such as insulin resistance, hypertension, and neoplasia. In this context, this review describes the relationships of the abovementioned pathologies with leptin.
肥胖是绝经后乳腺癌的重要危险因素，也是癌症患者预后不良的因素。此外，肥胖与多种健康问题相关，如胰岛素抵抗/2型糖尿病、高血压和其他心血管疾病。这些健康问题常表现为代谢综合征的组成部分/并发症。然而，肥胖相关疾病可能与绝经后乳腺癌共存，且这些合并症可能很严重。因此，可以推测包括乳腺癌在内的不同疾病可能源于过度脂肪组织中的共同病理背景。脂肪细胞释放的激素样细胞因子（或脂肪因子）瘦素在正常健康状态和肥胖状态下表现不同。越来越多的证据表明，瘦素在我们主要的肥胖相关健康问题中发挥重要作用，如胰岛素抵抗、高血压和肿瘤形成。在此背景下，本综述描述了上述病理与瘦素的关系。
