窝状角质松解症——各种临床表现的研究。

Pitted keratolysis - a study of various clinical manifestations.

机构信息

Department of Dermatology, Venereology and Leprology, H.B.T. Medical College and Dr. R.N. Cooper Hospital, Mumbai, Maharashtra, India.

出版信息

Int J Dermatol. 2017 Nov;56(11):1154-1160. doi: 10.1111/ijd.13744. Epub 2017 Sep 18.

Abstract

BACKGROUND

Pitted keratolysis (PK) is a common bacterial infection of skin characterized by noninflammatory superficial pits. Very few studies have focused on variations in clinical manifestations of PK. We conducted this study so that diagnosis of this treatable condition is not missed when it presents in an uncommonly perceived way.

AIMS AND OBJECTIVES

Assessment of PK patients for various sites and morphologies.

MATERIALS AND METHODS

A total of 30 patients with PK were assessed for various sites and morphologies. Bacterial and fungal cultures along with histopathology were performed.

RESULTS

Of 30 patients, 24 were females. Hyperhidrosis and malodour were the most common symptoms. Interdigital interface skin of the toes was the first site affected in most patients. Plantar skin was affected in all patients with involvement of interface skin of the toes in 29 patients. Other sites affected were palms, finger web spaces, nonglabrous skin, paronychium, and nail. Other than classical pits, scaly crusted inflammatory lesions with post-inflammatory hyperpigmentation (PIH) were noted. Associated keratoderma was also reported in some patients.

DISCUSSION

The presence of hyperhidrosis, malodour, and plantar lesions is consistent with previous studies. Interface skin between toes as the first site affected, involvement of toe web spaces, and associated keratoderma have been reported rarely. However, female preponderance, involvement of finger web spaces, nonglabrous skin, paronychium, nail changes, the presence of inflammation with crusting, and PIH have never been reported previously.

CONCLUSION

PK can involve web spaces, nonglabrous skin, and paronychium, and can cause nail changes. The lesions can be inflammatory with crusting and PIH.

摘要

背景

窝状角质松解症(PK)是一种常见的皮肤细菌感染,表现为非炎症性的浅表凹陷。很少有研究关注 PK 的临床表现变化。我们进行这项研究是为了避免在以不常见的方式出现时漏诊这种可治疗的疾病。

目的和目标

评估 PK 患者的各种部位和形态。

材料和方法

共评估了 30 例 PK 患者的各种部位和形态。进行了细菌和真菌培养以及组织病理学检查。

结果

30 例患者中,24 例为女性。多汗和臭味是最常见的症状。大多数患者最初受累的部位是趾间界面皮肤。足底皮肤受累见于所有患者,29 例患者的趾间界面皮肤受累。其他受累部位包括手掌、指蹼间隙、无角质皮肤、甲周皮肤和指甲。除了经典的凹陷外,还观察到鳞屑性结痂炎症性病变伴炎症后色素沉着(PIH)。一些患者还报告了相关的角化过度症。

讨论

多汗、臭味和足底病变的存在与之前的研究一致。趾间界面皮肤作为最初受累部位、趾蹼间隙受累以及相关的角化过度症的报道较少。然而,女性发病倾向、指蹼间隙受累、无角质皮肤、甲周皮肤、指甲改变、炎症性结痂和 PIH 的存在以前从未报道过。

结论

PK 可累及蹼间隙、无角质皮肤和甲周皮肤,并可引起指甲改变。病变可能伴有炎症性结痂和 PIH。

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