Hu Hui-Ling, Fu Chao-Mei, Zhao Xuan, Zhang Jin-Ming, Gao Fei, He Yao, Fu Shu, Li Ling
Pharmacy College, Chengdu University of Traditional Chinese Medicine, the Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu 611137, China.
University of Macao, Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research Macao University of Traditional Chinese Medicine, Macao 999078, China.
Zhongguo Zhong Yao Za Zhi. 2016 Sep;41(18):3483-3489. doi: 10.4268/cjcmm20161827.
The manufacturing process of Chinese medicines is the significant link to achieve "effect-enhancing and toxicity-reducing", including an interaction between "toxicity and effect". This paper would elucidate the effects of Chinese herbal compound decoction, preparation, dosage forms, route of administration and quality of pharmaceutical excipients on "toxicity-effect" theory from the formulation approaches. The article pointed out that the comprehensive analysis on "toxicity-effect" theory should be strengthened from the aspects of overall manufacturing, fundamental research and modern Chinese preparation, to explore the mechanism of "effect-enhancing and toxicity-reducing" in the manufacturing process, clarify the core status of Chinese preparation in "toxicity-effect" theory, and ensure the security and effectiveness in traditional Chinese medicine clinical application.
中药炮制是实现“增效减毒”的重要环节，其中存在“毒性与药效”的相互作用关系。本文将从制剂学角度阐述中药复方汤剂、制备工艺、剂型、给药途径及药用辅料质量对“毒性 - 药效”理论的影响。文章指出，应从整体炮制、基础研究及现代中药制剂等方面加强对“毒性 - 药效”理论的综合分析，探索炮制过程中“增效减毒”的机制，明确中药制剂在“毒性 - 药效”理论中的核心地位，确保中药临床应用的安全性和有效性。
