Hu Hui-Quan, Cheng Guo-Wang, Wu Yi-Feng, Zhang Yu-Tian, Wu Yi, Yang Yi-Qin, Yang Ming, Wu Zhen-Feng
Key Laboratory of Modern Preparation of Chinese Medicine, Ministry of Education, Jiangxi University of Chinese Medicine Nanchang 330004, China.
Key Laboratory of Modern Preparation of Chinese Medicine, Ministry of Education, Jiangxi University of Chinese Medicine Nanchang 330004, China State Key Laboratory of Innovation Drug and Efficient Energy-Saving Pharmaceutical Equipment, Jiangxi University of Chinese Medicine Nanchang 330004, China.
Zhongguo Zhong Yao Za Zhi. 2023 Apr;48(7):1800-1807. doi: 10.19540/j.cnki.cjcmm.20221129.302.
In recent years, the use of active substances as excipients or as substitutes for other excipients in the design of modern drug delivery systems has received widespread attention, which has promoted the development of the theory of unification of medicines and excipients in the design of traditional Chinese medicine(TCM) preparations. Adopting the theory of unification of medicines and excipients to design drug delivery systems can reduce the use of excipients and thus the cost of preparations, reduce drug toxicity, increase drug solubility and biocompatibility, enhance synergistic effect, and realize targeted delivery and simultaneous delivery of multiple components. However, the research on the application of this theory in the modern drug delivery system of TCM preparations is still insufficient, with few relevant articles. In addition, the TCM active substances that can be used as the excipients remain to be catalogued. In this paper, we review the types and applications of the drug delivery systems with TCM active substances as excipients and describe their common construction methods and mechanisms, aiming to provide references for the in-depth research on the modern drug delivery systems for TCM preparations.
近年来，活性物质作为辅料或替代其他辅料应用于现代药物递送系统的设计中受到广泛关注，这推动了中药制剂设计中“药辅合一”理论的发展。采用“药辅合一”理论设计药物递送系统可减少辅料用量，从而降低制剂成本，降低药物毒性，提高药物溶解度和生物相容性，增强协同效应，实现多成分靶向递送和同步递送。然而，该理论在中药制剂现代药物递送系统中的应用研究仍不充分，相关文献较少。此外，可作为辅料的中药活性物质有待梳理。本文综述了以中药活性物质为辅料的药物递送系统的类型及应用，并阐述了其常见构建方法和作用机制，旨在为深入研究中药制剂现代药物递送系统提供参考。
