通过重编程一名47，XXX综合征患者的外周血单个核细胞生成无整合诱导多能干细胞（GZHMUi001-A）
Generation of integration-free induced pluripotent stem cells (GZHMUi001-A) by reprogramming peripheral blood mononuclear cells from a 47, XXX syndrome patient.
作者信息
Chen Yuchang, Ou Zhanhui, Song Bing, Xian Yexing, Ouyang Shuming, Xie Yuhuan, Xue Yanting, Sun Xiaofang
机构信息
Key Laboratory for Reproduction and Genetics of Guangdong Higher Education Institutes, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510150, China.
Key Laboratory for Reproduction and Genetics of Guangdong Higher Education Institutes, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510150, China.
出版信息
Stem Cell Res. 2017 Aug;23:57-60. doi: 10.1016/j.scr.2017.06.002. Epub 2017 Jun 9.
47, XXX syndrome is one of several sex-chromosomal aneuploidies, and it has an incidence of approximately 1/1000 in newborn females. Because of heterogeneity in X-inactivation, these patients may exhibit a variety of clinical symptoms. Here, we report the generation of an integration-free human induced pluripotent stem cell line (GZHMUi001-A) by using Sendai virus to reprogram peripheral blood mononuclear cells from a 47, XXX syndrome patient with premature ovarian failure. This 47, XXX iPS cell line has characteristics of pluripotent stem cells and is a useful tool for the investigation of this X chromosome aneuploid disease.
47，XXX综合征是几种性染色体非整倍体疾病之一，在新生女性中的发病率约为1/1000。由于X染色体失活的异质性，这些患者可能表现出多种临床症状。在此，我们报告了通过使用仙台病毒对一名患有卵巢早衰的47，XXX综合征患者的外周血单个核细胞进行重编程，从而产生了一株无整合的人诱导多能干细胞系（GZHMUi001-A）。该47，XXX诱导多能干细胞系具有多能干细胞的特征，是研究这种X染色体非整倍体疾病的有用工具。
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