从一名患有嵌合型特纳综合征的卵巢早衰患者中生成诱导多能干细胞系NTUHi001-A。
Generation of induced pluripotent stem cell line-NTUHi001-A from a premature ovarian failure patient with Turner's syndrome mosaicism.
作者信息
Lu Chen-Yu, Chen Yu-An, Syu Shih-Han, Lu Huai-En, Ho Hong-Nerng, Chen Hsin-Fu
机构信息
Graduate Institute of Medical Genomics and Proteomics, College of Medicine, National Taiwan University, Taipei, Taiwan.
Bioresource Collection and Research Center, Food Industry Research and Development Institute, Hsinchu, Taiwan.
出版信息
Stem Cell Res. 2019 May;37:101422. doi: 10.1016/j.scr.2019.101422. Epub 2019 Apr 2.
Turner's syndrome (TS) is one of the main causes of premature ovarian failure (POF). However, the mechanisms underlying POF are difficult to study due to the lack of suitable disease models. Herein, we have generated a human induced pluripotent stem cell (hiPSC) line derived from the peripheral blood mononuclear cells of a female patient with Turner's syndrome mosaicism via integration-free Sendai-virus system. The hiPSCs were confirmed with a 45, X karyotype and the acquisition of pluripotency. It's likely that hiPSCs can serve as a feasible cellular model for further pathophysiological studies of POF cases, especially for those originating in TS.
特纳综合征（TS）是卵巢早衰（POF）的主要原因之一。然而，由于缺乏合适的疾病模型，POF的潜在机制难以研究。在此，我们通过无整合仙台病毒系统，从一名患有嵌合型特纳综合征的女性患者的外周血单个核细胞中生成了一条人诱导多能干细胞（hiPSC）系。这些hiPSC经确认具有45,X核型并获得了多能性。hiPSC很可能可作为一种可行的细胞模型，用于POF病例尤其是源于TS的POF病例的进一步病理生理学研究。
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