具有不同脂质组成的聚合物纳米盘和大纳米盘。
Polymer nanodiscs and macro-nanodiscs of a varying lipid composition.
作者信息
Ramadugu Venkata Sudheer Kumar, Di Mauro Giacomo Maria, Ravula Thirupathi, Ramamoorthy Ayyalusamy
机构信息
Biophysics Program and Department of Chemistry, The University of Michigan, Ann Arbor, MI 48109-1055, USA.
出版信息
Chem Commun (Camb). 2017 Sep 28;53(78):10824-10826. doi: 10.1039/c7cc06409h.
Abstract
Polymer lipid nanodiscs have enabled some exciting structural biology and nanobiotechnology applications. The use of a small molecular weight polymer (SMA-EA) has been demonstrated to dramatically increase the size of nanodiscs (up to ∼60 nm diameter). Here, we report the first demonstration of the formation of macro-nanodiscs for a variety of lipids, and solid-state NMR experiments utilizing their magnetic-alignment properties.
摘要
聚合物脂质纳米盘已经实现了一些令人兴奋的结构生物学和纳米生物技术应用。使用小分子量聚合物（SMA-EA）已被证明能显著增加纳米盘的尺寸（直径可达约60纳米）。在此，我们首次展示了多种脂质形成大尺寸纳米盘的过程，以及利用其磁取向特性进行的固态核磁共振实验。
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