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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Yoshino M, Murakami K, Katsumata Y, Takabayashi A, Mori S

Department of Biochemistry, Yokohama City University School of Medicine, Japan.

Comp Biochem Physiol B. 1987;88(2):651-4. doi: 10.1016/0305-0491(87)90358-0.

Plasma lactate and pyruvate were increased more markedly in fed rats than in fasted rats exposed to an 8000 m altitude. 2. The increase in plasma lactate and pyruvate was enhanced and inhibited by the alpha 1-adrenergic antagonist prazosin and the beta-blocker propranolol, respectively, in fasted rats exposed to an 8000 m altitude. Blood glucose was not changed by adrenergic blockades under the same conditions. 3. Prazosin and propranolol showed no effect on glycolytic metabolites in plasma in fed rats submitted to an 8000 m altitude. Blood glucose of fed rats was increased by alpha 1-blockade during severe hypoxia. 4. In fasted rats whose energy metabolism depends on oxidation mainly, alpha 1- and beta-adrenergic receptors can participate in the stimulation of respiration and the glycogen degradation, respectively, during an exposure to severe hypoxia. In fed rats energy metabolism depends on glycolysis, which utilizes blood glucose as the substrate preferentially during hypoxia.

与处于8000米海拔高度的禁食大鼠相比，进食大鼠的血浆乳酸和丙酮酸升高更为明显。2. 在处于8000米海拔高度的禁食大鼠中，α1-肾上腺素能拮抗剂哌唑嗪和β-阻滞剂普萘洛尔分别增强和抑制了血浆乳酸和丙酮酸的升高。在相同条件下，肾上腺素能阻滞剂对血糖没有影响。3. 哌唑嗪和普萘洛尔对处于8000米海拔高度的进食大鼠血浆中的糖酵解代谢产物没有影响。在严重缺氧期间，α1-阻滞剂使进食大鼠的血糖升高。4. 在主要依赖氧化代谢的禁食大鼠中，在暴露于严重缺氧期间，α1-和β-肾上腺素能受体可分别参与呼吸刺激和糖原降解。在进食大鼠中，能量代谢依赖糖酵解，在缺氧期间优先利用血糖作为底物。

Yoshino M, Murakami K, Katsumata Y, Takabayashi A, Mori S

Department of Biochemistry, Yokohama City University School of Medicine, Japan.

Comp Biochem Physiol B. 1987;88(2):651-4. doi: 10.1016/0305-0491(87)90358-0.

Plasma lactate and pyruvate were increased more markedly in fed rats than in fasted rats exposed to an 8000 m altitude. 2. The increase in plasma lactate and pyruvate was enhanced and inhibited by the alpha 1-adrenergic antagonist prazosin and the beta-blocker propranolol, respectively, in fasted rats exposed to an 8000 m altitude. Blood glucose was not changed by adrenergic blockades under the same conditions. 3. Prazosin and propranolol showed no effect on glycolytic metabolites in plasma in fed rats submitted to an 8000 m altitude. Blood glucose of fed rats was increased by alpha 1-blockade during severe hypoxia. 4. In fasted rats whose energy metabolism depends on oxidation mainly, alpha 1- and beta-adrenergic receptors can participate in the stimulation of respiration and the glycogen degradation, respectively, during an exposure to severe hypoxia. In fed rats energy metabolism depends on glycolysis, which utilizes blood glucose as the substrate preferentially during hypoxia.

与处于8000米海拔高度的禁食大鼠相比，进食大鼠的血浆乳酸和丙酮酸升高更为明显。2. 在处于8000米海拔高度的禁食大鼠中，α1-肾上腺素能拮抗剂哌唑嗪和β-阻滞剂普萘洛尔分别增强和抑制了血浆乳酸和丙酮酸的升高。在相同条件下，肾上腺素能阻滞剂对血糖没有影响。3. 哌唑嗪和普萘洛尔对处于8000米海拔高度的进食大鼠血浆中的糖酵解代谢产物没有影响。在严重缺氧期间，α1-阻滞剂使进食大鼠的血糖升高。4. 在主要依赖氧化代谢的禁食大鼠中，在暴露于严重缺氧期间，α1-和β-肾上腺素能受体可分别参与呼吸刺激和糖原降解。在进食大鼠中，能量代谢依赖糖酵解，在缺氧期间优先利用血糖作为底物。