Huo Xiaodong, Huo Bin, Wang Huixing, Zhang Hongdian, Ma Zhao, Yang Mingjian, Wang Haitao, Yu Zhentao
Department of Esophageal Cancer, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin 300060, P.R. China.
Department of Oncology, Second Hospital of Tianjin Medical University, Tianjin 300211, P.R. China.
Oncol Lett. 2017 Sep;14(3):2683-2690. doi: 10.3892/ol.2017.6559. Epub 2017 Jul 8.
Zinc finger E-box-binding homeobox 2 (ZEB2) has been reported to mediate epithelial-mesenchymal transition (EMT) and disease progression in several cancer types. However, the expression of ZEB2 in esophageal squamous cell carcinoma (OSCC) and its association with prognosis remains unclear. In the present study, a tissue microarray and immunohistochemistry were used to investigate ZEB2 and epithelial (E-)cadherin expression in OSCC tissues (n=218) and peritumoral esophageal tissues (POT; n=60). There was a significantly increased incidence of positive ZEB2 expression in OSCC tissues compared with the expression in POTs (P<0.012). By contrast, the incidence of positive E-cadherin expression in OSCC tissues was significantly decreased compared with the expression in POTs (P<0.004). ZEB2 expression in OSCC was associated with a number of clinicopathological factors, and it was also an independent predictive factor for shorter overall survival time (P<0.001). Overall, ZEB2 may promote OSCC metastasis and is a potential prognostic marker for malignancy.
据报道，锌指E盒结合同源盒蛋白2（ZEB2）在多种癌症类型中介导上皮-间质转化（EMT）和疾病进展。然而，ZEB2在食管鳞状细胞癌（OSCC）中的表达及其与预后的关系仍不清楚。在本研究中，使用组织芯片和免疫组化方法研究ZEB2和上皮（E-）钙黏蛋白在OSCC组织（n = 218）和癌旁食管组织（POT；n = 60）中的表达。与POTs中的表达相比，OSCC组织中ZEB2阳性表达的发生率显著增加（P < 0.012）。相比之下，与POTs中的表达相比，OSCC组织中E-钙黏蛋白阳性表达的发生率显著降低（P < 0.004）。OSCC中ZEB2的表达与许多临床病理因素相关，并且它也是总生存时间较短的独立预测因素（P < 0.001）。总体而言，ZEB2可能促进OSCC转移，并且是恶性肿瘤的潜在预后标志物。
