Departments of Obstetrics and Gynecology, and.
Pathology, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China.
Int J Gynecol Cancer. 2017 Sep;27(7):1343-1349. doi: 10.1097/IGC.0000000000001037.
This study aimed to evaluate the prognosis significance of zinc-finger E-box binding homeobox 2 (ZEB2) and transforming growth factor β1 (TGF-β1) as well as other clinical characteristics in epithelial ovarian cancer (EOC).
This retrospective study examined the expressions of ZEB2 and TGF-β1 in 64 EOC specimens, 36 benign ovarian tumor specimens, and 28 normal ovarian specimens by immunohistochemistry. The correlation of the expressions of ZEB2 and TGF-β1 was analyzed by the Spearman rank correlation analysis. The Kaplan-Meier method was used to construct crude survival curves, and the prognostic roles of ZEB2 and TGF-β1 as well as clinical characteristics were evaluated by Cox proportional hazards regression analysis.
The positive expression rates of ZEB2 and TGF-β1 were increased in EOC specimens compared with benign ovarian tumor and normal ovary specimens ( < 0.05), and ZEB2 expression was positively correlated with TGF-β1 expression ( = 0.538, = 0.000). In addition, the overall survival rate of EOC patients was associated with the expressions of ZEB2 and TGF-β1, age, differentiated grade, International Federation of Gynecology and Obstetrics (FIGO) stage, preoperative serum CA125 level, postoperative start time of chemotherapy, and treatment course (all < 0.05). Multivariate Cox regression demonstrated that FIGO stage ( = 0.033), TGF-β1 expression ( = 0.043), postoperative start time of chemotherapy ( = 0.009), and treatment course ( = 0.000) were prognostic factors for EOC.
ZEB2 and TGF-β1 may promote EOC progression, and FIGO stage, TGF-β1 expression, postoperative start time of chemotherapy, and treatment course may be associated with the prognosis of EOC.
本研究旨在评估锌指 E 盒结合同源盒 2（ZEB2）和转化生长因子 β1（TGF-β1）以及其他临床特征在卵巢上皮癌（EOC）中的预后意义。
本回顾性研究通过免疫组织化学法检测了 64 例 EOC 标本、36 例良性卵巢肿瘤标本和 28 例正常卵巢标本中 ZEB2 和 TGF-β1 的表达。采用 Spearman 秩相关分析分析 ZEB2 和 TGF-β1 的表达相关性。采用 Kaplan-Meier 法构建粗生存曲线，采用 Cox 比例风险回归分析评估 ZEB2 和 TGF-β1 以及临床特征的预后作用。
与良性卵巢肿瘤和正常卵巢组织相比，EOC 组织中 ZEB2 和 TGF-β1 的阳性表达率升高（<0.05），且 ZEB2 表达与 TGF-β1 表达呈正相关（=0.538，=0.000）。此外，EOC 患者的总生存率与 ZEB2 和 TGF-β1 的表达、年龄、分化程度、国际妇产科联合会（FIGO）分期、术前血清 CA125 水平、术后化疗开始时间和治疗疗程有关（均<0.05）。多因素 Cox 回归分析表明，FIGO 分期（=0.033）、TGF-β1 表达（=0.043）、术后化疗开始时间（=0.009）和治疗疗程（=0.000）是 EOC 的预后因素。
ZEB2 和 TGF-β1 可能促进 EOC 进展，FIGO 分期、TGF-β1 表达、术后化疗开始时间和治疗疗程可能与 EOC 的预后有关。
