DNA片段D7S13（pB79a）与囊性纤维化基因座的连锁关系。
Linkage of the DNA-segment D7S13 (pB79a) with the cystic fibrosis locus.
作者信息
Böhm D, Krawczak M, Schmidtke J
机构信息
Institut für Humangenetik der Universität, Göttingen, Federal Republic of Germany.
出版信息
Hum Genet. 1988 Feb;78(2):186-7. doi: 10.1007/BF00278194.
PMID:2892783
Abstract
A map distance of 2.9 cM between D7S13 (pB79a) and the cystic fibrosis (CF) locus was obtained from the analysis of 13 informative families with a history of CF. This result is based solely on the HindIII restriction fragment length polymorphism (HindIII-RFLP) at D7S13, since the interpretation of the MspI-RFLP at this locus was found to be unreliable.
摘要
通过对13个有囊性纤维化（CF）病史的信息丰富的家系进行分析，得出D7S13（pB79a）与囊性纤维化基因座之间的图距为2.9厘摩。该结果仅基于D7S13处的HindIII限制性片段长度多态性（HindIII-RFLP），因为发现该基因座处MspI-RFLP的解释不可靠。
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