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Chromosome assignment and restriction fragment length polymorphism analysis of the anonymous DNA probe B79a at 7q22 (HMG8 assignment D7S13).

作者信息

Estivill X, Schmidtke J, Williamson R, Wainwright B

出版信息

Hum Genet. 1986 Nov;74(3):320-2. doi: 10.1007/BF00282558.

DOI:10.1007/BF00282558
PMID:2877942
Abstract

The anonymous DNA fragment B79a, which had previously been located to chromosome 7cen-7q22, has been more accurately assigned to 7q22 by dosage analysis in a patient hemizygous for a deletion of that region. By examination of a panel of genomic DNAs from unrelated individuals, digested with a number of different restriction enzymes, we have identified two frequent RFLPs detected by B79a. This probe will be important in the analysis of cystic fibrosis which has been mapped to the region around 7q22.

摘要

相似文献

1
Chromosome assignment and restriction fragment length polymorphism analysis of the anonymous DNA probe B79a at 7q22 (HMG8 assignment D7S13).
Hum Genet. 1986 Nov;74(3):320-2. doi: 10.1007/BF00282558.
2
Linkage of DNA probe B79a (D7S13) to cystic fibrosis.DNA探针B79a（D7S13）与囊性纤维化的连锁关系。
Am J Hum Genet. 1987 Nov;41(5):944-7.
3
Localization of DNA probes with tight linkage to the cystic fibrosis locus by in situ hybridization using fibroblasts with a 7q22 deletion.
Hum Genet. 1988 Oct;80(2):161-4. doi: 10.1007/BF00702861.
4
Isolation of a polymorphic genomic clone from chromosome 7. Physical and genetic linkage studies to markers around the cystic fibrosis locus.从7号染色体分离出一个多态性基因组克隆。对囊性纤维化基因座周围标记进行物理和遗传连锁研究。
Hum Genet. 1987 Oct;77(2):122-6. doi: 10.1007/BF00272377.
5
Mapping of DNA markers linked to the cystic fibrosis locus on the long arm of chromosome 7.与位于7号染色体长臂上的囊性纤维化基因座相关的DNA标记的定位。
Am J Hum Genet. 1987 Mar;40(3):228-36.
6
Regional assignment of 41 human DNA fragments on chromosome 7 by means of a somatic cell hybrid panel.
Hum Genet. 1990 Jan;84(2):147-50. doi: 10.1007/BF00208929.
7
Regional localization of three probes closely linked to the cystic fibrosis locus by deletion analysis.
Cytogenet Cell Genet. 1987;44(2-3):101-2. doi: 10.1159/000132352.
8
The human cytochrome P450 CYP3 locus: assignment to chromosome 7q22-qter.人类细胞色素P450 CYP3基因座：定位于染色体7q22 - qter。
Hum Genet. 1989 Jan;81(2):171-4. doi: 10.1007/BF00293896.
9
Microdissection and microcloning of human chromosome 7q22-32 region.人类染色体7q22 - 32区域的显微切割与微克隆
Somat Cell Mol Genet. 1990 Mar;16(2):123-8. doi: 10.1007/BF01233042.
10
Three additional DNA polymorphisms in the met gene and D7S8 locus: use in prenatal diagnosis of cystic fibrosis.
J Pediatr. 1987 Oct;111(4):490-5. doi: 10.1016/s0022-3476(87)80106-3.

引用本文的文献

1
Exclusion of catalytic and regulatory subunits of cAMP-dependent protein kinase as candidate genes for the defect causing cystic fibrosis.排除环磷酸腺苷（cAMP）依赖性蛋白激酶的催化亚基和调节亚基作为导致囊性纤维化缺陷的候选基因。
Am J Hum Genet. 1987 Nov;41(5):925-32.
2
Genetic markers on chromosome 7.7号染色体上的遗传标记。
J Med Genet. 1988 May;25(5):294-306. doi: 10.1136/jmg.25.5.294.
3
Two rearranged MET alleles in MNNG-HOS cells reveal the orientation of MET on chromosome 7 to other markers tightly linked to the cystic fibrosis locus.

本文引用的文献

1
The human met oncogene is related to the tyrosine kinase oncogenes.人类原癌基因与酪氨酸激酶原癌基因相关。
Nature. 1985;318(6044):385-8. doi: 10.1038/318385a0.
2
Isolation of a further anonymous informative DNA sequence from chromosome seven closely linked to cystic fibrosis.从七号染色体上分离出另一个与囊性纤维化紧密连锁的匿名信息性DNA序列。
Nucleic Acids Res. 1986 Mar 11;14(5):1951-6. doi: 10.1093/nar/14.5.1951.
3
A closely linked genetic marker for cystic fibrosis.一种与囊性纤维化紧密连锁的遗传标记。
MNNG-HOS细胞中的两个重排MET等位基因揭示了7号染色体上MET与紧密连锁于囊性纤维化位点的其他标记物的方向。
Proc Natl Acad Sci U S A. 1988 Apr;85(8):2667-71. doi: 10.1073/pnas.85.8.2667.
4
Localization of DNA probes with tight linkage to the cystic fibrosis locus by in situ hybridization using fibroblasts with a 7q22 deletion.
Hum Genet. 1988 Oct;80(2):161-4. doi: 10.1007/BF00702861.
5
The gene for the alpha i1 subunit of human guanine nucleotide binding protein maps near the cystic fibrosis locus.人类鸟嘌呤核苷酸结合蛋白α i1亚基的基因定位于囊性纤维化基因座附近。
Am J Hum Genet. 1988 Jun;42(6):884-8.
6
Uniparental disomy as a mechanism for human genetic disease.单亲二体作为人类遗传疾病的一种机制。
Am J Hum Genet. 1988 Feb;42(2):217-26.
7
Linkage of the DNA-segment D7S13 (pB79a) with the cystic fibrosis locus.DNA片段D7S13（pB79a）与囊性纤维化基因座的连锁关系。
Hum Genet. 1988 Feb;78(2):186-7. doi: 10.1007/BF00278194.
8
Linkage of DNA probe B79a (D7S13) to cystic fibrosis.DNA探针B79a（D7S13）与囊性纤维化的连锁关系。
Am J Hum Genet. 1987 Nov;41(5):944-7.
9
Crossovers in two German cystic fibrosis families determine probe order for MET, 7C22 and XV-2c/CS.7.两个德国囊性纤维化家族中的交叉情况确定了MET、7C22和XV - 2c/CS.7的探针顺序。
Hum Genet. 1987 Oct;77(2):197-9. doi: 10.1007/BF00272392.
10
Isolation of a polymorphic genomic clone from chromosome 7. Physical and genetic linkage studies to markers around the cystic fibrosis locus.从7号染色体分离出一个多态性基因组克隆。对囊性纤维化基因座周围标记进行物理和遗传连锁研究。
Hum Genet. 1987 Oct;77(2):122-6. doi: 10.1007/BF00272377.
Nature. 1985;318(6044):382-4. doi: 10.1038/318382a0.
4
Localisation of a sequence, 7C22, showing close linkage to the cystic fibrosis locus.
Cytogenet Cell Genet. 1987;44(1):41-2. doi: 10.1159/000132338.
5
Regional mapping of six cloned DNA sequences on human chromosome 7.人类7号染色体上六个克隆DNA序列的区域定位。
Am J Hum Genet. 1986 Mar;38(3):280-7.
6
Cystic fibrosis carrier detection using a linked gene probe.使用连锁基因探针进行囊性纤维化携带者检测。
J Med Genet. 1986 Aug;23(4):295-9. doi: 10.1136/jmg.23.4.295.
7
Localization of cystic fibrosis locus to human chromosome 7cen-q22.囊性纤维化基因座定位于人类染色体7cen-q22。
Nature. 1985;318(6044):384-5. doi: 10.1038/318384a0.
8
Linkage relationships of paraoxonase (PON) with other markers: indication of PON-cystic fibrosis synteny.
Clin Genet. 1985 Oct;28(4):265-71. doi: 10.1111/j.1399-0004.1985.tb00400.x.
9
Cystic fibrosis locus defined by a genetically linked polymorphic DNA marker.由基因连锁多态性DNA标记物定义的囊性纤维化位点。
Science. 1985 Nov 29;230(4729):1054-7. doi: 10.1126/science.2997931.
10
First-trimester prenatal diagnosis of cystic fibrosis with linked DNA probes.运用连锁DNA探针进行孕早期囊性纤维化的产前诊断。
Lancet. 1986 Jun 21;1(8495):1402-5. doi: 10.1016/s0140-6736(86)91553-9.