Ser Hooi-Leng, Tan Wen-Si, Ab Mutalib Nurul-Syakima, Yin Wai-Fong, Chan Kok-Gan, Goh Bey-Hing, Lee Learn-Han
Monash University Malaysia, School of Pharmacy, Novel Bacteria and Drug Discovery (NBDD) Research Group, Selangor Darul Ehsan, Malaysia; Monash University Malaysia, Jeffrey Cheah School of Medicine and Health Sciences, Biomedical Research Laboratory, Selangor Darul Ehsan, Malaysia.
University of Malaya, Institute of Biological Sciences, Division of Genetics and Molecular Biology, Kuala Lumpur, Malaysia.
Braz J Microbiol. 2018 Jan-Mar;49(1):13-15. doi: 10.1016/j.bjm.2017.01.013. Epub 2017 Sep 6.
As the largest genus in Actinobacteria family, Streptomyces species have the ability to synthesize numerous compounds of diverse structures with bioactivities. Streptomyces mangrovisoli MUSC 149 was previously isolated as a novel streptomycete from mangrove forest in east coast of Peninsular Malaysia. The high quality draft genome of MUSC 149 comprises 9,165,825bp with G+C content of 72.5%. Through bioinformatics analysis, 21 gene clusters identified in the genome were associated with the production of bioactive secondary metabolites. The presence of these biosynthetic gene clusters in MUSC 149 suggests the potential exploitation of the strain for production of medically important compounds.
作为放线菌科中最大的属,链霉菌属具有合成众多结构多样且具有生物活性的化合物的能力。红树林链霉菌MUSC 149先前是从马来西亚半岛东海岸的红树林中分离出来的一种新型链霉菌。MUSC 149的高质量草图基因组包含9,165,825bp,G+C含量为72.5%。通过生物信息学分析,在基因组中鉴定出的21个基因簇与生物活性次级代谢产物的产生有关。MUSC 149中这些生物合成基因簇的存在表明该菌株在生产医学上重要的化合物方面具有潜在的开发价值。