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A群流感嗜血杆菌：外膜蛋白分类及其与荚膜位点DNA多态性的相关性

Haemophilus influenzae serotype a: outer membrane protein classification and correlation with DNA polymorphism at the cap locus.

作者信息

Allan I, Kroll J S, Dhir A, Moxon E R

机构信息

Department of Paediatrics, John Radcliffe Hospital, Headington, Oxford, United Kingdom.

出版信息

Infect Immun. 1988 Feb;56(2):529-31. doi: 10.1128/iai.56.2.529-531.1988.

DOI:10.1128/iai.56.2.529-531.1988
PMID:2892798
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC259315/
Abstract

Fifty-four temporally and geographically distinct isolates of Haemophilus influenzae serotype a were characterized by (i) outer membrane protein composition and (ii) DNA polymorphism at the cap locus. In 53 of 54 cases, knowledge of the outer membrane protein type was accurately predictive of the cap locus polymorphism, suggesting that the majority of H. influenzae (type a) isolates have evolved from a limited number of clones.

摘要

对54株在时间和地理上均有差异的a型流感嗜血杆菌分离株进行了如下特征分析：（i）外膜蛋白组成，以及（ii）cap位点的DNA多态性。在54例中的53例中，外膜蛋白类型的信息能够准确预测cap位点的多态性，这表明大多数a型流感嗜血杆菌分离株是由数量有限的克隆株进化而来。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b16c/259315/8c0739eff176/iai00074-0246-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b16c/259315/3a63d5e3d2d6/iai00074-0246-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b16c/259315/8c0739eff176/iai00074-0246-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b16c/259315/3a63d5e3d2d6/iai00074-0246-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b16c/259315/8c0739eff176/iai00074-0246-b.jpg

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2
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本文引用的文献

1
Subtyping isolates of Haemophilus influenzae type b by outer-membrane protein profiles.通过外膜蛋白谱对b型流感嗜血杆菌分离株进行分型
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Cloning of chromosomal DNA from Haemophilus influenzae. Its use for studying the expression of type b capsule and virulence.流感嗜血杆菌染色体DNA的克隆。其用于研究b型荚膜的表达及毒力。
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Pediatr Infect Dis. 1984 Nov-Dec;3(6):575-7.
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Cleavage of structural proteins during the assembly of the head of bacteriophage T4.在噬菌体T4头部组装过程中结构蛋白的切割
Nature. 1970 Aug 15;227(5259):680-5. doi: 10.1038/227680a0.
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Arch Dis Child. 1985 Dec;60(12):1193-6. doi: 10.1136/adc.60.12.1193.
7
A population genetic framework for the study of invasive diseases caused by serotype b strains of Haemophilus influenzae.用于研究b型流感嗜血杆菌菌株引起的侵袭性疾病的群体遗传学框架。
Proc Natl Acad Sci U S A. 1985 Aug;82(15):5078-82. doi: 10.1073/pnas.82.15.5078.
8
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Microb Pathog. 1987 Feb;2(2):139-45. doi: 10.1016/0882-4010(87)90105-7.
9
Difference in structure between type b and nontypable Haemophilus influenzae populations.b型流感嗜血杆菌与不可分型流感嗜血杆菌群体之间的结构差异。
Infect Immun. 1986 Jul;53(1):79-89. doi: 10.1128/iai.53.1.79-89.1986.
10
Genetic relationships of serologically nontypable and serotype b strains of Haemophilus influenzae.流感嗜血杆菌血清学不可分型及b型菌株的遗传关系。
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