Tolba Osama Abd Rab Elrasol, El-Shanshory Mohamed Ramadan, El-Gamasy Mohamed Abd Elaziz, El-Shehaby Walid Ahmed
Department of Pediatric, Faculty of Medicine, Tanta University, Tanta, Gharbia, Egypt.
Ann Pediatr Cardiol. 2017 Sep-Dec;10(3):230-233. doi: 10.4103/apc.APC_140_16.
Cardiac dysfunction is a risk factor for death in patients with sickle cell disease (SCD).
Aim of the work is to evaluate the right ventricular systolic and diastolic functions by tissue Doppler and speckling tracking imaging in children with SCD.
Thirty children with SCD and thirty controls were subjected to clinical, laboratory evaluations, and echocardiographic study using GE Vivid 7 (GE Medical System, Horten, Norway with a 3.5-MHz multifrequency transducer) including; Two-dimensional and tissue Doppler echocardiographic study (lateral tricuspid valve annulus peak E' velocity, lateral tricuspid valve annulus peak A' velocity, E'/A' ratio, isovolumetric relaxation time, lateral tricuspid valve annulus S' and septal S' waves and peak longitudinal systolic strain [PLSS] and time to PLSS) were done in six right ventricular segments.
There was a significant decrease in right ventricular systolic and diastolic function in patients group when compared to controls.
Children with SCD have impaired right ventricular systolic and diastolic functions when compared to healthy children with early evaluation of the systolic dysfunction by speckle tracking imaging technique.
心脏功能障碍是镰状细胞病（SCD）患者死亡的危险因素。
本研究旨在通过组织多普勒和斑点追踪成像评估SCD患儿的右心室收缩和舒张功能。
30例SCD患儿和30例对照者接受了临床、实验室评估，并使用GE Vivid 7（GE医疗系统公司，挪威霍滕，配备3.5兆赫多频探头）进行了超声心动图研究，包括：对六个右心室节段进行二维和组织多普勒超声心动图研究（三尖瓣环侧壁E'峰速度、三尖瓣环侧壁A'峰速度、E'/A'比值、等容舒张时间、三尖瓣环侧壁S'波和室间隔S'波以及纵向收缩期峰值应变[PLSS]和达到PLSS的时间）。
与对照组相比，患者组右心室收缩和舒张功能显著降低。
与健康儿童相比，SCD患儿的右心室收缩和舒张功能受损，斑点追踪成像技术可早期评估收缩功能障碍。
