Agha Hala Mounir, Ibrahim Hossam, El Satar Inas Abd, El Rahman Naglae Abd, El Aziz Doaa Abd, Salah Zeinab, El Saeidi Sonia, Mostafa Fatma, Attia Wael, El Rahman Mohamed Abd, El Mohsen Gaser Abd
Pediatric Cardiology Division, Department of Pediatrics, Faculty of Medicine, Specialized Pediatric Hospital, Cairo University, Kasr Al Aini Street, Cairo, 11562, Egypt.
Pediatr Cardiol. 2017 Apr;38(4):819-827. doi: 10.1007/s00246-017-1588-7. Epub 2017 Mar 18.
To evaluate the right ventricular (RV) function in relation to that of the left ventricle (LV) in patients with dilated cardiomyopathy (DCM). Echocardiographic examination was done using tissue Doppler imaging (TDI) and two-dimensional speckle tracking echocardiography (2D-STE) for 32 pediatric patients with DCM comparing them to another 32 normal matched controls. The global longitudinal strain (GLS) derived from 2D-STE was used to reflect the LV systolic function. Tricuspid annular plan systolic excursion (TAPSE) and the following RV TDI derived indexes: peak systolic velocity (S'), peak early diastolic velocity E', peak late diastolic velocity A', isovolumic acceleration (IVA) and myocardial performance index (MPI) were measured. RV had significant systolic and diastolic dysfunction; TAPSE, S' velocity, IVA, peak early diastolic velocity (E') and peak early diastolic velocity/peak late diastolic velocity (E'/A') ratio were significantly decreased while MPI was significantly prolonged compared to controls. Moreover, TAPSE, S', IVA, E', E'/A' and RV MPI were significantly correlated to LV GLS. For prediction of LV dysfunction among patients, the area under the receiver operating characteristic curve was 0.98 for RV MPI, 0.906 for RV IVA. For identifying severe LV dysfunction; RV MPI > 0.29 had 100% sensitivity and 93.7% specificity, while the RV IVA ≤ 3 had 84.4% sensitivity and 90.6% specificity. In pediatric patients with DCM the RV systolic and diastolic functions are affected beside the LV dysfunction. Non-conventional echocardiographic evaluation of RV function is recommended in among this cohort.
评估扩张型心肌病(DCM)患者右心室(RV)功能与左心室(LV)功能的关系。对32例儿科DCM患者进行了组织多普勒成像(TDI)和二维斑点追踪超声心动图(2D-STE)检查,并与另外32例正常匹配对照进行比较。用2D-STE得出的整体纵向应变(GLS)来反映左心室收缩功能。测量三尖瓣环平面收缩期位移(TAPSE)以及以下右心室TDI衍生指标:收缩期峰值速度(S')、舒张早期峰值速度E'、舒张晚期峰值速度A'、等容加速(IVA)和心肌性能指数(MPI)。右心室存在明显的收缩和舒张功能障碍;与对照组相比,TAPSE、S'速度、IVA、舒张早期峰值速度(E')和舒张早期峰值速度/舒张晚期峰值速度(E'/A')比值显著降低,而MPI显著延长。此外,TAPSE、S'、IVA、E'、E'/A'和右心室MPI与左心室GLS显著相关。对于预测患者的左心室功能障碍,右心室MPI的受试者操作特征曲线下面积为0.98,右心室IVA为0.906。为识别严重左心室功能障碍;右心室MPI>0.29时敏感性为100%,特异性为93.7%,而右心室IVA≤3时敏感性为84.4%,特异性为90.6%。在患有DCM的儿科患者中,除左心室功能障碍外,右心室的收缩和舒张功能也受到影响。建议对该队列患者进行右心室功能的非常规超声心动图评估。