Pozo F, Fueyo A, Esteban M M, Rojo-Ortega J M, Marin B
Departamento Interfacultativo de Fisiología (Medicina-Biología), Facultad de Medicina, Universidad de Oviedo, Espagne.
J Physiol (Paris). 1987;82(1):18-24.
Neural and humoral mechanisms involved in the reflex pressor response during mechanical stimulation of the stomach of rats were investigated. The arterial blood pressure response was prevented by inhibition of alpha-adrenergic vasoconstriction using either an alpha-adrenergic blocker or a ganglionic blocker. In addition, there was a small decrease in the response after nephrectomy. However, there were no alterations in the response after beta-adrenergic blockade, bilateral adrenalectomy, inhibition of converting enzyme activity with enalapril or bilateral cervical vagus nerve transection. The heart rate was not modified after either intervention. After vagotomy the time of recovery of the basal blood pressure was significantly prolonged. It can be concluded that the blood pressure response to mechanical stimulation of the stomach wall is of neural rather than of humoral origin and mainly involves activation of alpha-adrenergic receptors. Vagal efferent pathways could be also involved.
研究了大鼠胃机械刺激期间反射性升压反应所涉及的神经和体液机制。使用α-肾上腺素能阻滞剂或神经节阻滞剂抑制α-肾上腺素能血管收缩可阻止动脉血压反应。此外，肾切除术后反应有小幅下降。然而，β-肾上腺素能阻断、双侧肾上腺切除、用依那普利抑制转化酶活性或双侧颈迷走神经横断后反应无改变。两种干预后心率均未改变。迷走神经切断术后基础血压恢复时间显著延长。可以得出结论，胃壁机械刺激引起的血压反应源于神经而非体液，主要涉及α-肾上腺素能受体的激活。迷走传出通路也可能参与其中。
