1st Department of Pediatrics, Semmelweis University, Budapest, Hungary.
MTA-SE, Pediatrics and Nephrology Research Group, Budapest, Hungary.
Pediatr Diabetes. 2018 Mar;19(2):300-304. doi: 10.1111/pedi.12569. Epub 2017 Sep 20.
Infections, mostly of viral origin, may contribute to the seasonal variation in the onset of type 1 diabetes mellitus (T1DM). The rs1990760 (A>G, Ala946Thr) polymorphism (GG genotype) of the interferon induced helicase (IFIH1), a virus recognition receptor, confers a modest protection for T1DM. The aim of our study was to evaluate a possible association between this IFIH1 polymorphism and the seasonal variation in the onset of T1DM.
The IFIH1 rs1990760 polymorphism was genotyped in 1055 patients of Central-Eastern European ancestry with T1DM (median age at diagnosis: 8.2 [interquartile range, IQR 4.8-11.8] years). T1DM onset was recorded in monthly intervals.
The IFIH1 genotype distribution was the following: 436 patients (41.3%) had AA genotype, 483 patients (45.8%) had AG genotype, and 136 patients (12.9%) had GG genotype. Significant seasonal variation in manifestation of T1DM (highest rate in winter and lowest rate in summer period) was observed in the total cohort (n = 1055), irrespective of gender. The disease predisposing AA genotype was more frequently found among new cases with onset in summer vs in those with onset in winter (44.3% vs 37.9%); conversely, the protective GG genotype was less frequent (9.3% vs 12.9%, respectively; P = .0268 for trend). Significant effect of genotype (P = .0418) was found on the seasonal variability of T1DM onset in the total cohort.
The IFIH1 rs1990760 polymorphism seems to be associated with the seasonal manifestation of T1DM. Our findings suggest that this virus receptor gene may contribute to T1DM manifestation primarily in the summer period.
感染，主要是病毒感染，可能导致 1 型糖尿病（T1DM）的发病呈季节性变化。干扰素诱导的螺旋酶（IFIH1）的 rs1990760（A>G，Ala946Thr）多态性（GG 基因型）是一种病毒识别受体，为 T1DM 提供了适度的保护。我们的研究目的是评估该 IFIH1 多态性与 T1DM 发病季节性之间的可能关联。
在 1055 名具有 T1DM 的中欧裔患者（中位诊断年龄：8.2[四分位间距，IQR 4.8-11.8]岁）中对 IFIH1 rs1990760 多态性进行了基因分型。以月为间隔记录 T1DM 的发病时间。
IFIH1 基因型分布如下：436 名患者（41.3%）为 AA 基因型，483 名患者（45.8%）为 AG 基因型，136 名患者（12.9%）为 GG 基因型。在总队列中观察到 T1DM 表现出明显的季节性变化（最高发病率在冬季，最低发病率在夏季），无论性别如何。在夏季发病的新病例中，疾病易感性 AA 基因型更为常见（44.3%比 37.9%）；相反，保护基因型 GG 则不太常见（分别为 9.3%比 12.9%；P=.0268 趋势）。在总队列中，基因型（P=.0418）对 T1DM 发病季节性的变化有显著影响。
IFIH1 rs1990760 多态性似乎与 T1DM 的季节性表现有关。我们的研究结果表明，这种病毒受体基因可能主要在夏季对 T1DM 的发病起作用。
