Thakur Garima, Prashanthi Kovur, Jiang Keren, Thundat Thomas
Department of Chemical and Materials Engineering, University of Alberta, Edmonton, Alberta T6G-1H9, Canada.
Biomolecules. 2017 Sep 20;7(3):69. doi: 10.3390/biom7030069.
Spontaneous self-assemblies of biomolecules can generate geometrical patterns. Our findings provide an insight into the mechanism of self-assembled ring pattern generation by human serum albumin (HSA). The self-assembly is a process guided by kinetic and thermodynamic parameters. The generated protein ring patterns display a behavior which is geometrically related to a -simplex model and is explained through thermodynamics and chemical kinetics.
生物分子的自发自组装能够产生几何图案。我们的研究结果为人类血清白蛋白（HSA）自组装生成环状图案的机制提供了深入见解。自组装是一个由动力学和热力学参数引导的过程。所生成的蛋白质环状图案呈现出一种与α - 单形模型在几何上相关的行为，并通过热力学和化学动力学进行解释。
