明斯克拖拉机厂工人的职业与慢性阻塞性肺疾病。
Occupation and chronic obstructive pulmonary disease in Minsk tractor plant workers.
机构信息
al-Farabi Kazakh National University, Almaty, Kazakhstan.
Biological institute, National Research Tomsk State University, Tomsk, Russian Federation.
出版信息
Am J Ind Med. 2017 Dec;60(12):1049-1055. doi: 10.1002/ajim.22776. Epub 2017 Sep 20.
BACKGROUND
The aim of this study was to measure the association of exposure to dust at workplace with COPD using objective methods of exposure and outcome classification.
METHODS
Forced expiratory volume in one second (FEV ) to forced vital capacity (FVC) <70%; FVC below LLN, and FEV below LLN from the annual screening of Minsk Tractor Plant workers (N = 458) were tested for predictors in an adjusted logistic regression model.
RESULTS
In a regression model, adjusted for pack-years of smoking, age, sex, and work duration, work in highly exposed workplaces was associated with FEV /FVC<70% (odds ratio (OR) 2.10 (95% confidence interval (CI) 1.16;3.83); and FEV <LLN (OR 2.24 (95% CI 1.18;4.25)). Given the fraction of workers exposed 0.20, population attributable fraction (PAF%) of COPD due to dust exposure was 18%.
CONCLUSIONS
Workers in highly exposed to dust workplaces had double odds of developing COPD.
背景
本研究旨在使用暴露和结局分类的客观方法来衡量工作场所粉尘暴露与 COPD 之间的关系。
方法
对明斯克拖拉机厂工人（n=458）进行年度筛查，测试用力呼气量（FEV）与用力肺活量（FVC）<70%；FVC 低于 LLN，以及 FEV 低于 LLN 的情况，以进行预测因子的调整逻辑回归模型。
结果
在调整了吸烟包年数、年龄、性别和工作时间的回归模型中，在高暴露工作场所工作与 FEV/FVC<70%（比值比（OR）2.10（95%置信区间（CI）1.16；3.83）；以及 FEV<LLN（OR 2.24（95% CI 1.18；4.25））相关。鉴于暴露工人的比例为 0.20，粉尘暴露导致 COPD 的人群归因分数（PAF%）为 18%。
结论
在高粉尘暴露工作场所工作的工人患 COPD 的几率增加了一倍。
Zotero 插件