Surgical Research Laboratories, Dept. of Surgery, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.
Surgical Research Laboratories, Dept. of Surgery, and Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.
Front Biosci (Landmark Ed). 2018 Jan 1;23(7):1310-1319. doi: 10.2741/4645.
Long interspersed nuclear elements (LINE-1) are well known as retrotransposons. A number of reports indicate that down-regulation of LINE-1 substantially affects growth of malignant cells and epithelial mesenchymal transition, which is difficult to be explained by its function as retrotransposon. More recent data indicate that LINE-1 is broadly involved in the regulation of telomere maintenance. This explains the essential role of LINE-1 for survival of malignant cells and further supports a global function of active LINE-1 elements in cell proliferation. We further discuss the implications of LINE-1-associated telomere regulation on evolution of telomeric structures, on embryogenesis and on therapy of malignancies.
长散布核元件（LINE-1）是众所周知的反转录转座子。许多报道表明，LINE-1 的下调显著影响恶性细胞的生长和上皮间质转化，这很难用其作为反转录转座子的功能来解释。最近的数据表明，LINE-1 广泛参与端粒维持的调控。这解释了 LINE-1 对恶性细胞存活的重要作用，并进一步支持活跃的 LINE-1 元件在细胞增殖中的全局功能。我们进一步讨论了 LINE-1 相关的端粒调控对端粒结构进化、胚胎发生和恶性肿瘤治疗的影响。
