中性粒细胞的发育必须“自噬”！
Developing Neutrophils Must Eat…Themselves!
机构信息
Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle Drive, La Jolla, CA 92037, USA.
Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle Drive, La Jolla, CA 92037, USA; Department of Bioengineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
出版信息
Immunity. 2017 Sep 19;47(3):393-395. doi: 10.1016/j.immuni.2017.08.013.
In this issue of Immunity, Riffelmacher et al. (2017) show that autophagy is necessary for the release of free fatty acids from intracellular stores within neutrophil precursor cells. This limits glycolysis, increases oxidative phosphorylation, and is essential for neutrophil maturation.
在本期《免疫》中，Riffelmacher 等人（2017 年）表明自噬对于从嗜中性粒细胞前体细胞内储存库中释放游离脂肪酸是必需的。这限制了糖酵解，增加了氧化磷酸化，并且对嗜中性粒细胞的成熟是必不可少的。
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