Kauvar Arielle N B, Keaney Terrence C, Alster Tina
New York Laser & Skin Care, New York, New York.
NYU School of Medicine, New York, New York.
Dermatol Surg. 2017 Dec;43(12):1434-1440. doi: 10.1097/DSS.0000000000001257.
Picosecond-domain laser pulses improve the photomechanical disruption of tattoos.
This study evaluates the efficacy and safety of a novel, dual-wavelength, 1,064/532-nm, picosecond-domain laser for tattoo clearance.
This was a prospective, self-controlled, clinical study of 34 subjects with 39 tattoos treated at 2 sites with an interval of 4.8 ± 1.6 weeks and up to 10 treatments (mean, 7.5). Blinded evaluation and investigator assessment of serial digital images was performed to evaluate treatment efficacy in the 36 tattoos that received at least 3 treatments. Investigators also assessed efficacy before each treatment visit up to 10 treatments. Safety and tolerability was evaluated for all 39 tattoos that underwent at least 1 treatment.
Blinded evaluation demonstrated that lightening of tattoos was achieved in all subjects, with 86% (31 of 36 tattoos) showing at least a 50% clearance after 3 treatments. Adverse events were few and transient in nature. Patient satisfaction and treatment tolerability were high.
Treatment of single-colored and multicolored tattoos with this novel 1,064/532-nm picosecond laser is highly safe and effective.
皮秒级激光脉冲可改善纹身的光机械破坏效果。
本研究评估一种新型的1064/532纳米双波长皮秒级激光清除纹身的疗效和安全性。
这是一项前瞻性、自身对照的临床研究，对34名受试者的39处纹身进行治疗，治疗在两个部位进行，间隔时间为4.8±1.6周，最多进行10次治疗（平均7.5次）。对接受至少3次治疗的36处纹身的连续数字图像进行盲法评估和研究者评估，以评估治疗效果。研究者还在每次治疗前（最多10次治疗）评估疗效。对所有接受至少1次治疗的39处纹身评估安全性和耐受性。
盲法评估表明，所有受试者的纹身均有变淡，86%（36处纹身中的31处）在3次治疗后显示至少50%的清除率。不良事件较少且为一过性。患者满意度和治疗耐受性较高。
用这种新型的1064/532纳米皮秒激光治疗单色和多色纹身具有高度的安全性和有效性。
