Department of Dermatology, Université Côte d'Azur, Centre Hospitalier Universitaire Nice, Nice, France.
Centre Dermatologique Esthétique et Laser, Grenoble, France.
J Eur Acad Dermatol Venereol. 2018 Feb;32(2):265-270. doi: 10.1111/jdv.14492. Epub 2017 Aug 21.
Q-switched nanosecond lasers demonstrated their efficacy in treating most types of tattoos, but complete disappearance is not always achieved even after performing numerous laser sessions. Picosecond lasers are supposed to be more efficient in clearing tattoos than nanosecond lasers, but prospective comparative data remain limited.
To compare on different types of tattoos the efficacy of a nanosecond laser with two types of picosecond lasers.
We conducted a prospective randomized study performed from December 2014 to June 2016 on adult patients with all types of tattoos. The tattoos were divided into two halves of equal size. After randomization, half of the tattoo was treated with a picosecond laser and the other half with a nanosecond laser. The evaluation was performed on standardized pictures performed before treatment and 2 months after the last session, by two physicians, not involved in the treatment, blinded on the type of treatments received. The main end point was a clearance above 75% of the tattoos.
A total of 49 patients were included. Professional tattoos represented 85.7%, permanent make-up 8.2% and non-professional tattoo 6.1%. The majority were black or blue and 10.2% were polychromatic. No patient was lost during follow-up. A reduction of 75% or more of the colour intensity was obtained for 33% of the tattoos treated with the picosecond lasers compared to 14% with the nanosecond laser (P = 0.008). An improvement superior to 75% was obtained in 34% monochromic black or blue tattoos with the picosecond lasers compared to 9% for the nanosecond laser. Only one of the five polychromic tattoos achieved more than 75% of improvement with the two types of laser.
Our results show a statistically significant superiority of the picosecond lasers compared to the nanosecond laser for tattoo clearance. However, they do not show better efficacy for polychromic tattoos and the difference in terms of side-effects was also minimal with a tendency of picosecond lasers to be less painful.
调 Q 纳秒激光已被证实对大多数类型的纹身治疗有效，但即使经过多次激光治疗，也并非总能完全去除纹身。皮秒激光被认为比纳秒激光在清除纹身方面更有效，但目前仍缺乏前瞻性的对比数据。
比较纳秒激光和两种皮秒激光在不同类型纹身中的疗效。
我们进行了一项前瞻性、随机对照研究，纳入了 2014 年 12 月至 2016 年 6 月期间所有类型纹身的成年患者。将纹身分为大小相等的两半，随机分组后，一半用皮秒激光治疗，另一半用纳秒激光治疗。治疗前和末次治疗后 2 个月，由两位未参与治疗的、对治疗类型设盲的医师对标准化照片进行评估。主要终点是纹身清除率达 75%以上。
共纳入 49 例患者，专业纹身占 85.7%，永久性化妆占 8.2%，非专业纹身占 6.1%；大多数纹身颜色为黑色或蓝色，10.2%为多色；所有患者均完成随访。皮秒激光组有 33%的纹身颜色强度减少 75%或以上，而纳秒激光组只有 14%（P=0.008）。皮秒激光组 34%的单色黑或蓝纹身改善程度超过 75%，而纳秒激光组只有 9%。两种激光均仅 1 例多色纹身改善程度超过 75%。
与纳秒激光相比，皮秒激光在清除纹身方面具有统计学显著优势。但皮秒激光在清除多色纹身方面并无优势，且两种激光的副作用差异也很小，皮秒激光的疼痛程度可能较低。
