Sharpe N, Murphy J, Smith H, Hannan S
Department of Medicine, University of Auckland School of Medicine, New Zealand.
Lancet. 1988 Feb 6;1(8580):255-9. doi: 10.1016/s0140-6736(88)90347-9.
In a randomised, double-blind trial 60 patients with left ventricular dysfunction (ejection fraction less than 45%) but without clinical evidence of heart failure 1 week after Q wave myocardial infarction were given captopril 25 mg thrice a day, frusemide 40 mg daily, or placebo. Left ventricular volumes were measured at baseline and at 1, 3, 6, 9, and 12 months with cross-sectional echocardiography and Simpson's rule analysis of standardised apical views. The captopril group showed no significant change in left ventricular end-diastolic volume index but left ventricular end-systolic volume index was significantly reduced and stroke volume index and ejection fraction were significantly increased from 1 month on. In contrast, the frusemide and placebo groups showed significant increases in ventricular volumes, with stroke volume index unchanged and ejection fraction slightly reduced. The changes in the captopril group were significantly different from those in the other groups.
在一项随机双盲试验中，60例左心室功能不全（射血分数低于45%）但在Q波心肌梗死后1周无心力衰竭临床证据的患者，被给予卡托普利25毫克每日三次、速尿40毫克每日一次或安慰剂。在基线以及第1、3、6、9和12个月时，采用横断面超声心动图和标准化心尖视图的辛普森法则分析来测量左心室容积。卡托普利组左心室舒张末期容积指数无显著变化，但左心室收缩末期容积指数从第1个月起显著降低，每搏输出量指数和射血分数显著增加。相比之下，速尿组和安慰剂组心室容积显著增加，每搏输出量指数不变，射血分数略有降低。卡托普利组的变化与其他组显著不同。
