Hooton T M, Roberts M C, Roberts P L, Holmes K K, Stamm W E, Kenny G E
Department of Medicine, Harborview Medical Center, University of Washington Affiliated Hospitals, School of Medicine, Seattle.
Lancet. 1988 Feb 6;1(8580):266-8. doi: 10.1016/s0140-6736(88)90350-9.
The prevalence of urethral infection with Mycoplasma genitalium was determined by use of a DNA probe in 203 men attending a sexually transmitted disease clinic. M genitalium was detected in 3 (14%) of 21 with acute gonococcal urethritis; 3 (10%) of 30 with acute chlamydia-positive non-gonococcal urethritis (NGU); 4 (13%) of 31 with acute chlamydia-negative NGU; 10 (27%) of 37 with persistent or recurrent NGU; and 10 (12%) of 84 with no urethritis. The organism was more prevalent in homosexual (11 [30%] of 37) than in heterosexual men (19 [11%] of 166; p = 0.009). These data do not support an important aetiological role for M genitalium in acute urethritis, but suggest that it may account for some cases of NGU that become persistent or recurrent. The higher prevalence of urethral infection in homosexual men suggests that M genitalium may reside in the gastrointestinal tract.
运用DNA探针，对203名前往性传播疾病诊所就诊的男性进行检测，以确定生殖支原体尿道感染的患病率。在21例急性淋菌性尿道炎患者中，检测到3例（14%）感染生殖支原体；30例急性衣原体阳性非淋菌性尿道炎（NGU）患者中，3例（10%）感染；31例急性衣原体阴性NGU患者中，4例（13%）感染；37例持续性或复发性NGU患者中，10例（27%）感染；84例无尿道炎患者中，10例（12%）感染。该病原体在同性恋男性（37例中的11例[30%]）中比在异性恋男性（166例中的19例[11%]；p = 0.009）中更为普遍。这些数据不支持生殖支原体在急性尿道炎中起重要病因学作用，但表明它可能是一些持续性或复发性NGU病例的病因。同性恋男性尿道感染患病率较高，提示生殖支原体可能存在于胃肠道。
