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聚合物负载硅转移试剂的设计、合成及在与有机锂试剂交叉偶联反应中的应用。

Design, Synthesis, and Application of Polymer-Supported Silicon-Transfer Agents for Cross-Coupling Reactions with Organolithium Reagents.

机构信息

Department of Chemistry, Laboratory for Research on the Structure of Matter and Monell Chemical Senses Center, University of Pennsylvania , Philadelphia, Pennsylvania 19104, United States.

出版信息

J Org Chem. 2017 Oct 20;82(20):11056-11071. doi: 10.1021/acs.joc.7b02004. Epub 2017 Oct 2.

DOI:10.1021/acs.joc.7b02004
PMID:28931273
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5664197/
Abstract

The initial design, synthesis, and validation of polymer-supported siloxane transfer agents have been achieved that permit the direct use of organolithium reagents in the palladium-catalyzed cross-coupling reactions. Through rational design, two generations of polymer support were developed that significantly simplify product purification and the transfer agent recycling.

摘要

已经实现了聚合物支撑的硅氧烷转移试剂的初步设计、合成和验证，这使得有机锂试剂能够直接用于钯催化的交叉偶联反应。通过合理的设计，开发了两代聚合物载体，这显著简化了产物的纯化和转移试剂的回收。

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