Jasmin G, Solymoss B, Proschek L
Ann N Y Acad Sci. 1979;317:338-48. doi: 10.1111/j.1749-6632.1979.tb56544.x.
Verapamil and prenylamine, which antagonize calcium influx into heart muscle cells, Dibenamine and propanolol, alpha and beta adrenergic bockers, respectively, and prostaglandin E1, which acts on permeability of cell membranes and on adrenergic neurotransmission, were all shown to markedly reduce the severity of heart lesions in UM-X7.1 cardiomyopathic hamsters. The beneficial effects of these compounds seen essentially preventive, in that they do not afford protection for fully developed skeletal muscle lesions. The occurrence of the pathologic changes in the myocardium coincides with an increased adrenergic nerve activity, and it is believed that these drugs function mainly by decreasing calcium conductivity across the sarcolemmal membranes of cardiocytes.
维拉帕米和普尼拉明可拮抗钙流入心肌细胞，分别为α和β肾上腺素能阻滞剂的酚苄明和普萘洛尔，以及作用于细胞膜通透性和肾上腺素能神经传递的前列腺素E1，均显示可显著减轻UM-X7.1心肌病仓鼠的心脏病变严重程度。这些化合物的有益作用基本上是预防性的，因为它们对完全发展的骨骼肌病变没有保护作用。心肌病理变化的发生与肾上腺素能神经活动增加同时出现，据信这些药物主要通过降低心肌细胞肌膜的钙电导率发挥作用。
