Jasmin G, Eu H Y
Ann N Y Acad Sci. 1979;317:46-58. doi: 10.1111/j.1749-6632.1979.tb56509.x.
Investigations of the fine structural changes observed in the hearts of cardiomyopathic hamsters at very early stages of the disease indicate that the initial changes involve the pericapillary mesenchymal cells. Other prominent features consist of hypercontraction of cardiocytes, disruption of intercalated disks, and eventual partitioning of cardiac cells, with myofibrillar lysis. The generalized plasma membrane defect allows a net increase in calcium influx and a depression in mitochondrial respiratory control ratios. These pathologic events are in accord with previously reported increases in myocardial sympathic nerve activity.
对心肌病仓鼠心脏在疾病极早期观察到的细微结构变化的研究表明，最初的变化涉及毛细血管周围的间充质细胞。其他显著特征包括心肌细胞过度收缩、闰盘破坏以及最终心肌细胞的分隔和肌原纤维溶解。普遍存在的质膜缺陷导致钙内流净增加和线粒体呼吸控制率降低。这些病理事件与先前报道的心肌交感神经活动增加一致。
