From the Departments of Epidemiology (B.C.T.K., S.L., F.J.W., M.K.I., B.H.S., M.A.I.), Internal Medicine (B.C.T.K., E.J.H., R.Z., B.H.S.), and Neurology (S.L., F.J.W., M.K.I.), Erasmus MC-University Medical Center Rotterdam; and Inspectorate of Health Care (B.C.T.K., B.H.S.), Utrecht, the Netherlands.
Neurology. 2017 Oct 17;89(16):1716-1722. doi: 10.1212/WNL.0000000000004517. Epub 2017 Sep 20.
To determine if serum magnesium levels are associated with the risk of all-cause dementia and Alzheimer disease.
Within the prospective population-based Rotterdam Study, we measured serum magnesium levels in 9,569 participants, free from dementia at baseline (1997-2008). Participants were subsequently followed up for incident dementia, determined according to the DSM-III-R criteria, until January 1, 2015. We used Cox proportional hazard regression models to associate quintiles of serum magnesium with incident all-cause dementia. We used the third quintile as a reference group and adjusted for age, sex, Rotterdam Study cohort, educational level, cardiovascular risk factors, kidney function, comorbidities, other electrolytes, and diuretic use.
Our study population had a mean age of 64.9 years and 56.6% were women. During a median follow-up of 7.8 years, 823 participants were diagnosed with all-cause dementia. Both low serum magnesium levels (≤0.79 mmol/L) and high serum magnesium levels (≥0.90 mmol/L) were associated with an increased risk of dementia (hazard ratio [HR] 1.32, 95% confidence interval [CI] 1.02-1.69, and HR 1.30, 95% CI 1.02-1.67, respectively).
Both low and high serum magnesium levels are associated with an increased risk of all-cause dementia. Our results warrant replication in other population-based studies.
确定血清镁水平与全因痴呆和阿尔茨海默病风险之间是否存在关联。
在前瞻性人群为基础的鹿特丹研究中，我们在 9569 名基线时无痴呆的参与者中测量了血清镁水平（1997-2008 年）。随后根据 DSM-III-R 标准对参与者进行了随访，以确定是否发生了新发痴呆症，随访至 2015 年 1 月 1 日。我们使用 Cox 比例风险回归模型将血清镁的五分位数与新发全因痴呆症相关联。我们将第三五分位数作为参考组，并调整了年龄、性别、鹿特丹研究队列、教育水平、心血管危险因素、肾功能、合并症、其他电解质和利尿剂的使用情况。
我们的研究人群平均年龄为 64.9 岁，56.6%为女性。在中位随访 7.8 年期间，823 名参与者被诊断为全因痴呆症。低血清镁水平（≤0.79mmol/L）和高血清镁水平（≥0.90mmol/L）均与痴呆风险增加相关（风险比 [HR] 1.32，95%置信区间 [CI] 1.02-1.69 和 HR 1.30，95% CI 1.02-1.67）。
低血清镁和高血清镁水平均与全因痴呆风险增加相关。我们的结果需要在其他基于人群的研究中得到复制。
