镁在疾病治疗和预防中的应用：新出现的机制和机遇。
Magnesium for disease treatment and prevention: emerging mechanisms and opportunities.
机构信息
Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.
Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.
出版信息
Trends Pharmacol Sci. 2024 Aug;45(8):708-722. doi: 10.1016/j.tips.2024.06.004. Epub 2024 Jul 16.
Abstract
Magnesium (Mg) is a commonly used dietary supplement for the prevention and treatment of diseases. However, the efficacy and mechanisms of action of Mg in most diseases have been controversial because of conflicting findings in earlier studies. Recent clinical and preclinical studies provide novel insights into the use of Mg for the treatment and prevention of diseases affecting different organ systems. In this review, we provide an overview of recent clinical evidence for, and controversies over, the medical benefits of Mg. In addition, we critically discuss recent advances in understanding the mechanisms of action of Mg, which could enable the development of novel targeted therapies.
摘要
镁（Mg）是一种常用的膳食补充剂，可用于预防和治疗疾病。然而，由于早期研究结果相互矛盾，Mg 在大多数疾病中的疗效和作用机制一直存在争议。最近的临床和临床前研究为 Mg 在治疗和预防影响不同器官系统的疾病方面的应用提供了新的见解。在这篇综述中，我们概述了最近关于 Mg 的医学益处的临床证据和争议。此外，我们还批判性地讨论了对 Mg 作用机制的理解的最新进展，这可能为开发新的靶向治疗方法提供依据。
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