Zaczek Agnieszka, Jóźwiak Paweł, Krześlak Anna
Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska, Katedra Cytobiochemii, Łódź.
Postepy Hig Med Dosw (Online). 2017 Sep 20;71(0):811-824. doi: 10.5604/01.3001.0010.4649.
BMI-1 (B-lymphoma Mo-MLV insertion region 1) protein is a constituent of Polycomb Repressive Complex 1 (PRC1) that via ubiquitination of histone H2A affects expression of many genes. BMI-1 is involved in cellular processes such as DNA repair, proliferation, growth, senescence and apoptosis. BMI-1 plays a key role in biology of stem cells including cancer stem cells by regulation of their self-renewal and differentiation. Accumulating evidence has revealed that overexpression of BMI-1 in many human cancers correlates with disease progression and therapy failure. The results of in vitro and in vivo studies confirm the involvement of BMI-1 in tumor initiation as well as invasion, metastasis and chemoresistance. Taking into account significant role of BMI1 in tumorigenesis, especially associated with cancer stem cells, it seems that this gene may be a promising target of anticancer therapies.
BMI-1（B淋巴细胞瘤莫洛尼鼠白血病病毒插入区域1）蛋白是多梳抑制复合物1（PRC1）的一个组成部分，它通过组蛋白H2A的泛素化作用影响许多基因的表达。BMI-1参与细胞过程，如DNA修复、增殖、生长、衰老和凋亡。BMI-1通过调节干细胞包括癌症干细胞的自我更新和分化，在干细胞生物学中发挥关键作用。越来越多的证据表明，BMI-1在许多人类癌症中的过表达与疾病进展和治疗失败相关。体外和体内研究结果证实BMI-1参与肿瘤起始以及侵袭、转移和化疗耐药。考虑到BMI1在肿瘤发生中的重要作用，特别是与癌症干细胞相关，看来该基因可能是抗癌治疗的一个有前景的靶点。
