Department of Cytobiochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Lodz, Poland, <
Cell Physiol Biochem. 2024 Oct 15;58(5):584-596. doi: 10.33594/000000733.
Breast cancer is the most frequent cancer among women. Despite extensive research in recent years the molecular basis of breast cancer development, growth and metastasis remains unclear. Numerous studies highlight the involvement of BMI-1 in tumorigenesis. BMI-1 protein is a key component of Polycomb Repressive Complex 1, which by ubiquitinylation of histone H2A, regulates expression of genes involved in various cellular processes including cell cycle, proliferation and programmed cell death. Overexpression of BMI-1 has been often associated with breast cancer development and progression. This review summarizes the current state of knowledge of BMI-1's role in breast cancer biology and its potential significance as prognostic marker and potential target of new anticancer therapy.
乳腺癌是女性最常见的癌症。尽管近年来在医学研究领域进行了广泛的研究，但乳腺癌的发生、发展和转移的分子基础仍不清楚。许多研究强调了 BMI-1 在肿瘤发生中的作用。BMI-1 蛋白是 Polycomb 抑制复合物 1 的关键组成部分，通过泛素化组蛋白 H2A，调节参与各种细胞过程的基因的表达，包括细胞周期、增殖和程序性细胞死亡。BMI-1 的过度表达常与乳腺癌的发生和发展有关。本文综述了 BMI-1 在乳腺癌生物学中的作用及其作为预后标志物和新的抗癌治疗潜在靶点的潜在意义的最新研究进展。
