Takahashi Masaki, Toki Shoichi, Yamashita Yukitaka, Kaneko Akihiro
Department of Radiology, Aomorishintoshi Hospital.
Department of Radiology, Nakamura Memorial Hospital.
Nihon Hoshasen Gijutsu Gakkai Zasshi. 2017;73(9):731-736. doi: 10.6009/jjrt.2017_JSRT_73.9.731.
It is reported that pharmacokinetics after intravenous injection of I-ioflupane may reflect cerebral blood flow. In this study, the early-phase pharmacokinetics of I-ioflupane in 10 healthy volunteers was analyzed over time using dynamic single-photon emission computed tomography (SPECT) immediately after intravenous injection. We also examined the correlation between the I-IMP imaging and the I-ioflupane early-phase image for 14 cases in which both dopamine transporter (DaT) imaging by I-ioflupane and cerebral blood flow imaging by I-IMP were performed on the same camera. The time-activity curve between cerebellum (CBL) area and each area of anterior cerebral artery (ACA), middle cerebral artery (MCA), posterior cerebral artery (PCA) showed distribution characteristics similar to I-IMP from immediately after intravenous injection until 20 minutes after administration, and there was no conspicuous washout. The regression line and the correlation coefficient of the Z-score of three-dimensional stereotactic surface projections (3DSSP) (decrease) of the early-phase imaging of I-ioflupane and the I-IMP imaging are y=0.7546x+0.3562, r=0.8169 (P<0.01) at 0-10 minutes of I-ioflupane, and y=0.7412x+0.3027, r=0.8280 (P<0.01) at 0-15 minutes of I-ioflupane, and y=0.7400x+0.2456, r=0.8449 (P<0.01) at 0-20 minutes of I-ioflupane, showing a strong correlation at all timings. Therefore, I-ioflupane early-phase pharmacokinetics after intravenous showed distribution characteristics similar to I-IMP, indicating the possibility that early images may be useful in a clinical practice.
据报道，静脉注射碘氟潘后的药代动力学可能反映脑血流量。在本研究中，对10名健康志愿者静脉注射碘氟潘后，立即使用动态单光子发射计算机断层扫描（SPECT）随时间分析其早期药代动力学。我们还对14例在同一台相机上同时进行碘氟潘多巴胺转运体（DaT）成像和碘[123I]异碘普胺（I-IMP）脑血流成像的病例，检查了I-IMP成像与碘氟潘早期图像之间的相关性。小脑（CBL）区域与大脑前动脉（ACA）、大脑中动脉（MCA）、大脑后动脉（PCA）各区域之间的时间-活性曲线显示，从静脉注射后即刻至给药后20分钟，其分布特征与I-IMP相似，且无明显洗脱。碘氟潘早期成像与I-IMP成像的三维立体定向表面投影（3DSSP）（降低）的Z分数的回归线和相关系数在碘氟潘0 - 10分钟时为y = 0.7546x + 0.3562，r = 0.8169（P < 0.01），在碘氟潘0 - 15分钟时为y = 0.7412x + 0.3027，r = 0.8280（P < 0.01），在碘氟潘0 - 20分钟时为y = 0.7400x + 0.2456，r = 0.8449（P < 0.01），在所有时间点均显示出强相关性。因此，静脉注射后碘氟潘的早期药代动力学显示出与I-IMP相似的分布特征，表明早期图像在临床实践中可能有用。
