1 Department of Radiology, Brooke Army Medical Center, Fort Sam Houston, 3551 Roger Brooke Dr, San Antonio, TX 78234.
2 Department of Radiology, Uniformed Services University, Bethesda, MD.
AJR Am J Roentgenol. 2019 Aug;213(2):243-253. doi: 10.2214/AJR.19.21088. Epub 2019 Apr 17.
The purpose of this article is to provide a review of I-ioflupane SPECT in the evaluation of suspected parkinsonian syndromes (PSs). This collection of diseases presents frequent diagnostic challenges, even by movement disorder and dementia specialists. The I-ioflupane scan serves as an imaging biomarker of the status of presynaptic dopamine transporters (DATs) in the striatum. As a result of neuronal death, DATs are greatly reduced in patients with PS neurodegenerative disorders, whereas clinical mimics generally do not show striatal DAT loss. This provides a tremendous opportunity for I-ioflupane to aid in the accurate and timely diagnosis of these patients and optimize their management.
本文旨在综述碘[123I]-β-单-正丙基碘苯（I-ioflupane）SPECT 检查在疑似帕金森综合征（PS）患者中的应用。此类疾病的诊断极具挑战性，即使是运动障碍和痴呆方面的专家也难以明确诊断。I-ioflupane 扫描可作为纹状体中突触前多巴胺转运体（DAT）状态的影像学生物标志物。由于神经元死亡，PS 神经退行性疾病患者的 DAT 大量减少，而临床类似疾病患者一般不会出现纹状体 DAT 缺失。这为 I-ioflupane 辅助准确、及时地诊断这些患者并优化其管理提供了绝佳的机会。
