Mantero Marco, Rogliani Paola, Di Pasquale Marta, Polverino Eva, Crisafulli Ernesto, Guerrero Monica, Gramegna Andrea, Cazzola Mario, Blasi Francesco
Department of Pathophysiology and Transplantation, Università degli Studi di Milano.
Internal Medicine Department, Respiratory Unit and Regional Adult Cystic Fibrosis Center, IRCCS Fondazione Cà Granda Ospedale Maggiore Policlinico, Milan.
Int J Chron Obstruct Pulmon Dis. 2017 Sep 8;12:2687-2693. doi: 10.2147/COPD.S145253. eCollection 2017.
Acute exacerbations are a leading cause of worsening COPD in terms of lung function decline, quality of life, and survival. They also have a relevant economic burden on the health care system. Determining the risk factors for acute exacerbation and early relapse could be a crucial element for a better management of COPD patients. This review analyzes the current knowledge and underlines the main risk factors for recurrent acute exacerbations. Comprehensive evaluation of COPD patients during stable phase and exacerbation could contribute to prevent treatment failure and relapses.
就肺功能下降、生活质量和生存率而言,急性加重是慢性阻塞性肺疾病(COPD)病情恶化的主要原因。它们还给医疗保健系统带来了相当大的经济负担。确定急性加重和早期复发的风险因素可能是更好地管理COPD患者的关键因素。本综述分析了当前的知识,并强调了反复急性加重的主要风险因素。在稳定期和加重期对COPD患者进行综合评估有助于预防治疗失败和复发。