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关于蚊子在布氏杆菌溃疡病原体传播中作用不大的证据。 （注：原文中“the Causative Agent of Buruli Ulcer”前少了病原体名称，推测可能是某种细菌等，这里先按完整结构翻译，实际需根据准确原文补充完整病原体信息）

Evidences of the Low Implication of Mosquitoes in the Transmission of , the Causative Agent of Buruli Ulcer.

作者信息

Djouaka Rousseau, Zeukeng Francis, Daiga Bigoga Jude, N'golo Coulibaly David, Tchigossou Genevieve, Akoton Romaric, Aboubacar Sylla, Tchebe Sodjinin Jean-Eudes, Nantcho Nguepdjo Clavella, Adeoti Razack, Djegbe Innocent, Tamo Manuele, Mbacham Wilfred Fon, Kakou-Ngazoa Solange E, Ablordey Anthony

机构信息

AgroEcoHealth Platform, International Institute of Tropical Agriculture (IITA), 08 P.O. Box 0932, Tri-Postal, Cotonou, Benin.

Faculty of Science, Department of Biochemistry, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon.

出版信息

Can J Infect Dis Med Microbiol. 2017;2017:1324310. doi: 10.1155/2017/1324310. Epub 2017 Aug 28.

DOI:10.1155/2017/1324310
PMID:28932250
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5592421/
Abstract

BACKGROUND

Buruli ulcer (BU) continues to be a serious public health threat in wet tropical regions and the mode of transmission of its etiological agent, (), remains poorly understood. In this study, mosquito species collected in endemic villages in Benin were screened for the presence of . In addition, the ability of mosquitoes larvae to pick up from their environment and remain colonized through the larval developmental stages to the adult stage was investigated.

METHODS

7,218 adults and larvae mosquitoes were sampled from endemic and nonendemic villages and screened for DNA targets (, , and KR-B) using qPCR. was not detected in any of the field collected samples. Additional studies of artificially infected larvae of with strains revealed that mosquitoes larvae are able to ingest and host during L1, L2, L3, and L4 developmental stages. However, we noticed an absence of these bacteria at both pupae and adult stages, certainly revealing the low ability of infected or colonized mosquitoes to vertically transmit to their offspring.

CONCLUSION

The overall findings highlight the low implication of mosquitoes as biological vectors in the transmission cycle of from the risk environments to humans.

摘要

背景

布鲁里溃疡（BU）在潮湿热带地区仍然是严重的公共卫生威胁，其病原体（）的传播方式仍知之甚少。在本研究中，对在贝宁流行村庄采集的蚊虫种类进行了筛查，以检测是否存在（）。此外，还研究了蚊虫幼虫从环境中获取（）并在从幼虫发育阶段到成虫阶段保持定殖的能力。

方法

从流行和非流行村庄采集了7218只成虫和幼虫蚊虫，使用qPCR检测（）的DNA靶点（、和KR-B）。在任何野外采集的样本中均未检测到（）。对（）的人工感染幼虫与（）菌株的进一步研究表明，蚊虫幼虫在L1、L2、L3和L4发育阶段能够摄取并宿存（）。然而，我们注意到在蛹期和成虫期均不存在这些细菌，这肯定表明受感染或定殖的蚊虫将（）垂直传播给其后代的能力较低。

结论

总体研究结果突出表明，蚊虫作为生物媒介在（）从风险环境传播给人类的传播循环中作用不大。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/718b/5592421/65da5659e5a9/CJIDMM2017-1324310.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/718b/5592421/5211bfc40ccd/CJIDMM2017-1324310.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/718b/5592421/65da5659e5a9/CJIDMM2017-1324310.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/718b/5592421/5211bfc40ccd/CJIDMM2017-1324310.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/718b/5592421/65da5659e5a9/CJIDMM2017-1324310.002.jpg

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