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治疗对老年急性肾损伤患者短期预后的影响

The Effect of Treatment on Short-Term Outcomes in Elderly Patients with Acute Kidney Injury.

作者信息

Petronijevic Zvezdana, Selim Gjulsen, Petkovska Lidija, Georgievska-Ismail Ljubica, Spasovski Goce, Tozija Liljana

机构信息

University Clinic of Nephrology, Medical Faculty, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia.

University Clinic of Toxicology, Medical Faculty, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia.

出版信息

Open Access Maced J Med Sci. 2017 Aug 9;5(5):635-640. doi: 10.3889/oamjms.2017.148. eCollection 2017 Aug 15.

Abstract

BACKGROUND

Elderly population (≥ 65) are more prone to develop acute kidney injury (AKI) compared to younger, also elderly with AKI have an increased requirement for dialysis treatment and an elevated risk of short-term and long-term mortality.

AIM

The objectives of this study were to examine the effect of treatment of short-term outcomes and mortality in elderly patients with AKI.

MATERIAL AND METHODS

Seventy elderly AKI patients, that filled one of the criteria of AKI definition and had hospitalization over 24 hours, were enrolled in the study.

RESULTS

The median age of patients was 74.28 ± 6.64, with mean CCI (Charlson Comorbidity Index) score of 6.94 ± 1.94. The majority of patients (70%) were classified at stage 3 of AKIN, 20% of patients were classified at stage 2 and 10% at stage 1. In the groups of patients with death outcome, the chronic cardiomyopathy was more frequently present (p = 0.034). Regarding treatment, 58.6% of the AKI patients underwent hemodialysis while 41.4% received conservative treatment. Mortality rate was 52.8%, out of which 28.6% was in-hospital mortality, while in 24.3% of patients death occurred in the follow-up period of 90 days.

CONCLUSION

In our study, short- term survival is not related to different treatment options. Applied treatment in elderly patients with AKI should be assessed by measuring the long term outcome.

摘要

背景

与年轻人相比,老年人群(≥65岁)更易发生急性肾损伤(AKI),而且老年AKI患者对透析治疗的需求增加,短期和长期死亡风险升高。

目的

本研究的目的是探讨治疗对老年AKI患者短期结局和死亡率的影响。

材料与方法

70例符合AKI定义标准之一且住院超过24小时的老年AKI患者纳入本研究。

结果

患者的中位年龄为74.28±6.64岁,平均Charlson合并症指数(CCI)评分为6.94±1.94。大多数患者(70%)被分类为AKIN 3期,20%的患者被分类为2期,10%为1期。在死亡结局的患者组中,慢性心肌病更为常见(p=0.034)。关于治疗,58.6%的AKI患者接受血液透析,而41.4%接受保守治疗。死亡率为52.8%,其中28.6%为住院死亡率,24.3%的患者在90天随访期内死亡。

结论

在我们的研究中,短期生存与不同的治疗选择无关。老年AKI患者的应用治疗应通过测量长期结局来评估。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33dc/5591594/2c170ca9e0bc/OAMJMS-5-635-g001.jpg

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