Bandara Basnayake Duminda, Kannangara Thamara, Welagedara Laknath, Bandara Vindhya, Herath Janitha
Department of Medicine, Teaching Hospital Kandy, Sri lanka.
Department of Haematology, Teaching Hospital Kandy, Sri lanka.
Caspian J Intern Med. 2017 Summer;8(3):217-219. doi: 10.22088/cjim.8.3.217.
Systemic lupus erythematosus (SLE) is an inflammatory autoimmune disorder which is uncommon in men. It has a wide variety of clinical presentations.
We report a 21-year-old male presented with one month history of fever, loss of appetite, weight loss and reduced hair growth with an examination revealing an oral ulcer, cervical and axillary lymphadenopathy simulating hematological malignancy. Investigations showed pancytopenia, positive anti-nuclear factor and double-stranded DNA, high erythrocyte sedimentation rate with normal C-reactive protein levels and hypocomplementemia. The diagnosis of systemic lupus erythematosus was made and treatment with oral prednisolone conferred a dramatic clinical and biochemical improvement within one week.
In the evaluation of fever of unknown origin, one should be guided by the presenting symptoms and signs of a patient and even though uncommon, SLE is a worthwhile diagnosis to investigate even in a male patient if the clinical picture is suggestive.
系统性红斑狼疮（SLE）是一种炎症性自身免疫性疾病，在男性中并不常见。它有各种各样的临床表现。
我们报告一名21岁男性，有1个月的发热、食欲不振、体重减轻和毛发生长减少病史，检查发现口腔溃疡、颈部和腋窝淋巴结肿大，类似血液系统恶性肿瘤。检查显示全血细胞减少、抗核因子和双链DNA阳性、红细胞沉降率升高而C反应蛋白水平正常以及补体血症。诊断为系统性红斑狼疮，口服泼尼松龙治疗在1周内使临床和生化指标有显著改善。
在评估不明原因发热时，应根据患者的症状和体征进行判断，即使SLE在男性中不常见，但如果临床表现提示，即使是男性患者，SLE也是一个值得调查的诊断。
