Harrigan Robert L, Smith Alex K, Lyttle Bailey, Box Bailey, Landman Bennett A, Bagnato Francesca, Pawate Siddharama, Smith Seth A
Department of Electrical Engineering, Vanderbilt University, USA.
Vanderbilt University Institute for Imaging Science, Vanderbilt University, USA.
Mult Scler J Exp Transl Clin. 2017 Sep 13;3(3):2055217317730097. doi: 10.1177/2055217317730097. eCollection 2017 Jul-Sep.
Optic neuritis (ON) is one of the most common presentations of multiple sclerosis (MS). Magnetic resonance imaging (MRI) of the optic nerves is challenging because of retrobulbar motion, orbital fat and susceptibility artifacts from maxillary sinuses; therefore, axonal loss is investigated with the surrogate measure of a single heuristically defined point along the nerve as opposed to volumetric investigation.
The objective of this paper is to derive optic nerve volumetrics along the entire nerve length in patients with MS and healthy controls in vivo using high-resolution, clinically viable MRI.
An advanced, isotropic T2-weighted turbo spin echo MRI was applied to 29 MS patients with (14 patients ON+) or without (15 patients ON-) history of ON and 42 healthy volunteers. An automated tool was used to estimate and compare whole optic nerve and surrounding cerebrospinal fluid radii along the length of the nerve.
Only ON+ MS patients had a significantly reduced optic nerve radius compared to healthy controls in the central segment of the optic nerve. Using clinically available MRI methods, we show and quantify ON volume loss for the first time in MS patients.
视神经炎（ON）是多发性硬化症（MS）最常见的表现之一。由于球后运动、眶内脂肪以及上颌窦的磁化率伪影，对视神经进行磁共振成像（MRI）具有挑战性；因此，与容积研究相反，轴突损失是通过沿神经单一启发式定义点的替代测量来研究的。
本文的目的是使用高分辨率、临床可行的MRI在体内得出MS患者和健康对照者沿整个神经长度的视神经容积。
对29例有（14例ON+）或无（15例ON-）ON病史的MS患者以及42名健康志愿者应用先进的各向同性T2加权快速自旋回波MRI。使用自动化工具估计并比较沿神经长度的整个视神经和周围脑脊液半径。
与健康对照相比，仅ON+ MS患者在视神经中央段的视神经半径显著减小。使用临床可用的MRI方法，我们首次在MS患者中显示并量化了ON的体积损失。
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