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异常的N400语义启动效应可能反映精神分裂症的精神病理过程：一项双胞胎研究。

Abnormal N400 Semantic Priming Effect May Reflect Psychopathological Processes in Schizophrenia: A Twin Study.

作者信息

Sharma Anuradha, Sauer Heinrich, Hill Holger, Kaufmann Claudia, Bender Stephan, Weisbrod Matthias

机构信息

Research Group Neurocognition, Department of General Psychiatry, Centre for Psychosocial Medicine, Heidelberg University, Heidelberg, Germany.

Department of Psychiatry, University of Jena, Jena, Germany.

出版信息

Schizophr Res Treatment. 2017;2017:7163198. doi: 10.1155/2017/7163198. Epub 2017 Aug 28.

DOI:10.1155/2017/7163198
PMID:28932600
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5592423/
Abstract

OBJECTIVE

Activation of semantic networks is indexed by the N400 effect. We used a twin study design to investigate whether N400 effect abnormalities reflect genetic/trait liability or are related to psychopathological processes in schizophrenia.

METHODS

We employed robust linear regression to compare N400 and behavioral priming effects across 36 monozygotic twin pairs (6 pairs concordant for schizophrenia/schizoaffective disorder, 11 discordant pairs, and 19 healthy control pairs) performing a lexical decision task. Moreover, we examined the correlation between Brief Psychiatric Rating Scale (BPRS) score and the N400 effect and the influence of medication status on this effect.

RESULTS

Regression yielded a significant main effect of group on the N400 effect only in the direct priming condition ( = 0.003). Indirect condition and behavioral priming effect showed no significant effect of group. Planned contrasts with the control group as a reference group revealed that affected concordant twins had significantly reduced N400 effect compared to controls, and discordant affected twins had a statistical trend for reduced N400 effect compared to controls. The unaffected twins did not differ significantly from the controls. There was a trend for correlation between reduced N400 effect and higher BPRS scores, and the N400 effect did not differ significantly between medicated and unmedicated patients.

CONCLUSIONS

Reduced N400 effect may reflect disease-specific processes in schizophrenia implicating frontotemporal brain network in schizophrenia pathology.

摘要

目的

语义网络的激活以N400效应为指标。我们采用双生子研究设计来调查N400效应异常是反映遗传/特质易感性还是与精神分裂症的心理病理过程相关。

方法

我们运用稳健线性回归，比较了36对同卵双生子（6对精神分裂症/分裂情感性障碍一致对、11对不一致对和19对健康对照对）在执行词汇判断任务时的N400和行为启动效应。此外，我们检查了简明精神病评定量表（BPRS）得分与N400效应之间的相关性以及药物状态对该效应的影响。

结果

回归分析仅在直接启动条件下得出组对N400效应有显著主效应（ = 0.003）。间接条件和行为启动效应未显示组的显著效应。以对照组为参照组的计划对比显示，患病一致双生子与对照组相比N400效应显著降低，患病不一致双生子与对照组相比N400效应有降低的统计趋势。未患病双生子与对照组无显著差异。N400效应降低与较高的BPRS得分之间有相关趋势，且服药和未服药患者的N400效应无显著差异。

结论

N400效应降低可能反映精神分裂症中特定于疾病的过程，涉及精神分裂症病理中的额颞脑网络。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97cd/5592423/1ff4e75a0e7f/SCHIZORT2017-7163198.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97cd/5592423/17edc8842329/SCHIZORT2017-7163198.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97cd/5592423/102bf05ee0fb/SCHIZORT2017-7163198.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97cd/5592423/395775fc7ca9/SCHIZORT2017-7163198.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97cd/5592423/1ff4e75a0e7f/SCHIZORT2017-7163198.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97cd/5592423/17edc8842329/SCHIZORT2017-7163198.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97cd/5592423/102bf05ee0fb/SCHIZORT2017-7163198.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97cd/5592423/395775fc7ca9/SCHIZORT2017-7163198.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97cd/5592423/1ff4e75a0e7f/SCHIZORT2017-7163198.004.jpg

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