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接受恶性淋巴瘤化疗的非HIV感染孕妇肺炎:两例报告

Pneumonia in Non-HIV Pregnant Women Receiving Chemotherapy for Malignant Lymphoma: Two Case Reports.

作者信息

Fukutani Yuki, Chigusa Yoshitsugu, Kondoh Eiji, Kawasaki Kaoru, Io Shingo, Matsumura Noriomi

机构信息

Department of Gynecology and Obstetrics, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan.

出版信息

Case Rep Obstet Gynecol. 2017;2017:1073146. doi: 10.1155/2017/1073146. Epub 2017 Aug 28.

Abstract

pneumonia (PCP) is a life-threatening opportunistic infection that sometimes occurs in immunocompromised patients with human immunodeficiency virus (HIV). Here, we report two extremely rare cases of PCP in non-HIV pregnant women who underwent chemotherapy for malignant lymphoma. Case  1 is a 34-year-old primigravida who was diagnosed with Hodgkin's lymphoma. She received ABVD chemotherapy and developed PCP at 37 weeks of gestation. After the onset of PCP, emergent cesarean section was performed due to a nonreassuring fetal status. Case  2 is a 31-year-old multigravida with diffuse large B-cell lymphoma who was administered R-CHOP chemotherapy. At 34 weeks of gestation, she complained of dyspnea and developed PCP. She delivered her baby vaginally immediately after the onset of symptoms. Both patients were treated with sulfamethoxazole-trimethoprim (ST) and recovered shortly thereafter. The babies' courses were also uneventful. PCP remains a serious cause of death, especially in non-HIV patients, and, therefore, appropriate prophylaxis and a prompt diagnosis are imperative.

摘要

肺孢子菌肺炎(PCP)是一种危及生命的机会性感染,有时发生在感染人类免疫缺陷病毒(HIV)的免疫功能低下患者中。在此,我们报告两例极为罕见的非HIV感染孕妇发生PCP的病例,她们因恶性淋巴瘤接受了化疗。病例1是一名34岁的初产妇,被诊断为霍奇金淋巴瘤。她接受了ABVD化疗,并在妊娠37周时发生了PCP。PCP发病后,由于胎儿情况不佳,进行了紧急剖宫产。病例2是一名31岁的经产妇,患有弥漫性大B细胞淋巴瘤,接受了R-CHOP化疗。在妊娠34周时,她出现呼吸困难并发生了PCP。症状出现后立即经阴道分娩。两名患者均接受了磺胺甲恶唑-甲氧苄啶(ST)治疗,此后不久康复。婴儿的病程也很顺利。PCP仍然是一个严重的死亡原因,尤其是在非HIV患者中,因此,适当的预防和及时诊断至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc74/5592425/da9dfa805ee9/CRIOG2017-1073146.001.jpg

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