Calderón-Baturone Irene, Salsoso Rocío, Charpentier Elena, de Armas Yaxsier, Guadix Pilar, Morilla Rubén, Calderón Enrique J, Friaza Vicente
Programa de Doctorado en Ciencias de la Salud, Universidad de Sevilla, 41009 Seville, Spain.
Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío, Consejo Superior de Investigaciones Científicas/Universidad de Sevilla, 41013 Seville, Spain.
J Fungi (Basel). 2025 Apr 20;11(4):327. doi: 10.3390/jof11040327.
is an opportunistic fungus that causes severe pneumonia in immunosuppressed individuals. While colonization, a subclinical form of infection, has been studied in different populations, its implications during pregnancy remain poorly understood. Given the immune modulation of pregnancy, maternal colonization or infection may contribute to vertical transmission and neonatal respiratory complications. This scoping review aims to map the existing evidence on colonization/infection during pregnancy, identifying knowledge gaps, prevalence, risk factors, and potential neonatal outcomes. A systematic literature search was conducted in three databases following PRISMA-ScR guidelines. A total of 26 studies were included, covering pneumonia cases (n = 19) and colonization (n = 7). The review found that most pneumonia cases in pregnant women were associated with HIV before antiretroviral therapy. More recent cases were related to hematologic malignancies. colonization rates varied widely (5.4-46.5%). Evidence of vertical transmission was observed, but neonatal impact remains underexplored. This review highlights the need for HIV screening in pregnant women and the need to include in the diagnosis of pregnant women with pneumonia. Increased awareness and research on in pregnancy are necessary to improve maternal and neonatal outcomes. Future studies should focus on vertical transmission and neonatal respiratory health.
是一种机会性真菌,可在免疫抑制个体中引起严重肺炎。虽然定植(一种亚临床感染形式)已在不同人群中得到研究,但其在妊娠期间的影响仍知之甚少。鉴于妊娠的免疫调节作用,母体定植或感染可能导致垂直传播和新生儿呼吸并发症。本范围综述旨在梳理妊娠期间定植/感染的现有证据,识别知识空白、患病率、危险因素和潜在的新生儿结局。按照PRISMA-ScR指南在三个数据库中进行了系统的文献检索。共纳入26项研究,涵盖肺炎病例(n = 19)和定植(n = 7)。该综述发现,孕妇中的大多数肺炎病例在接受抗逆转录病毒治疗前与艾滋病毒有关。最近的病例与血液系统恶性肿瘤有关。定植率差异很大(5.4-46.5%)。观察到垂直传播的证据,但对新生儿的影响仍未得到充分研究。本综述强调了对孕妇进行艾滋病毒筛查的必要性,以及在诊断患有肺炎的孕妇时纳入(相关检测)的必要性。提高对妊娠期间(该真菌)的认识和开展相关研究对于改善母婴结局是必要的。未来的研究应关注垂直传播和新生儿呼吸健康。