Kawaguchi Makoto, Ito Keiichi, Shimazaki Hideyuki, Asano Tomohiko
Department of Urology, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513, Japan.
Department of Laboratory Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513, Japan.
Urol Case Rep. 2017 Sep 8;15:14-16. doi: 10.1016/j.eucr.2017.07.002. eCollection 2017 Nov.
The present case underwent right laparoscopic radical nephrectomy for collecting duct carcinoma (CDC). Recurrence occurred in the lung and the bone (skull and lumber vertebra) in 2011. Gemcitabine plus cisplatin (GC) chemotherapy and monthly zoledronic acid (ZA) was then started. The massive skull bone metastases were prominently reossified after several courses of the therapy. The patient received 16 courses of GC chemotherapy and monthly ZA, and pulmonary metastases and reossified skull bone metastases were stable for 23 months. Although we cannot verify the adoptive effect of ZA on the reossification, this combination may be effective for CDC bone metastases.
该病例因集合管癌（CDC）接受了右侧腹腔镜根治性肾切除术。2011年出现肺和骨（颅骨和腰椎）转移。随后开始使用吉西他滨联合顺铂（GC）化疗及每月一次的唑来膦酸（ZA）治疗。经过几个疗程的治疗后，大量颅骨骨转移灶明显重新骨化。患者接受了16个疗程的GC化疗及每月一次的ZA治疗，肺转移灶和重新骨化的颅骨骨转移灶稳定了23个月。虽然我们无法证实ZA对重新骨化的促进作用，但这种联合治疗可能对CDC骨转移有效。
