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肾移植受者集合管癌的有效治疗:一例报告

Effective treatment of collecting duct carcinoma in a recipient of a kidney transplant: A case report.

作者信息

Nascimento de Assis Tabata Carolina Faria, Rapatoni Liane, Segato Flavio Nogueira, Maciel Pontes Barbhara Thais, Muglia Valdair Francisco, Neto Miguel Moyses, Almeida Romao Elen

机构信息

Division of Nephrology, Department of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo 14048-900, Brazil.

Division of Clinical Oncology, Department of Medical Imaging, Haematology and Clinical Oncology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo 14048-900, Brazil.

出版信息

Oncol Lett. 2024 Sep 3;28(5):528. doi: 10.3892/ol.2024.14661. eCollection 2024 Nov.

Abstract

Collecting duct carcinoma (CDC) is a rare disease associated with a high mortality rate. The present study describes the case of a recipient of a kidney transplant with metastatic allograft CDC whose treatment was successful. The patient underwent nephrectomy, and chemotherapy with gemcitabine and cisplatin, while undergoing haemodialysis treatment and remained in remission after 6 years of follow-up. There is a lack of information about the treatment and clinical management of CDC; however, the combination of gemcitabine and cisplatin remains as first-line therapy. The challenge of this case was integrating chemotherapy sessions with dialysis therapy to maintain the effectiveness, tolerability and safety of the oncological treatment. In the present case report, the success of chemotherapy with gemcitabine and cisplatin was demonstrated in a metastatic renal allograft CDC in a patient with end-stage renal disease, with few side effects and no recurrence of the disease 6 years after the end of treatment.

摘要

集合管癌(CDC)是一种罕见疾病,死亡率很高。本研究描述了一例肾移植受者发生转移性移植肾CDC且治疗成功的病例。该患者接受了肾切除术,并使用吉西他滨和顺铂进行化疗,同时接受血液透析治疗,随访6年后仍处于缓解期。关于CDC的治疗和临床管理信息匮乏;然而,吉西他滨和顺铂联合用药仍是一线治疗方案。该病例的挑战在于将化疗疗程与透析治疗相结合,以维持肿瘤治疗的有效性、耐受性和安全性。在本病例报告中,对于一名终末期肾病患者的转移性移植肾CDC,吉西他滨和顺铂化疗取得了成功,治疗结束6年后副作用很少且疾病未复发。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a5b/11406419/76750f6f80c0/ol-28-05-14661-g00.jpg

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