Iadarola M J, Douglass J, Civelli O, Naranjo J R
Neurobiology and Anesthesiology Branch, National Institute of Dental Research, NIH, Bethesda, MD 20892.
NIDA Res Monogr. 1986;75:406-9.
Injection of a complete Freunds adjuvant-saline emulsion into the hindpaw of the rat induces a peripheral inflammatory process accompanied by pronounced increase (3 fold) in spinal cord dynorphin content. A marked increase (approximately 9 fold) in the mRNA coding for the preprodynorphin precursor accompanies the increase in peptide. The parallel elevations of the mRNA and peptide product suggest that an increased activity of dynorphin neurons occurs in spinal cord in response to altered afferent input due to the peripheral inflammatory process.
将完全弗氏佐剂 - 盐水乳剂注射到大鼠后爪会引发外周炎症过程，同时脊髓强啡肽含量显著增加（3倍）。前强啡肽原前体编码的mRNA显著增加（约9倍），伴随着肽含量的增加。mRNA和肽产物的平行升高表明，由于外周炎症过程导致传入输入改变，脊髓中强啡肽神经元的活性增加。
