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肝硬化中的肝腺瘤病

Hepatic adenomatosis in liver cirrhosis.

作者信息

Gordic Sonja, Thung Swan N, Roayaie Sasan, Wagner Mathilde, Taouli Bachir

机构信息

Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, Zurich, Switzerland.

出版信息

Eur J Radiol Open. 2017 Sep 9;4:115-117. doi: 10.1016/j.ejro.2017.08.001. eCollection 2017.

DOI:10.1016/j.ejro.2017.08.001
PMID:28932768
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5597816/
Abstract

Hepatocellular adenoma (HCA) is a benign liver tumor most frequently occurring in women using oral contraception. HCA develops in normal or nearly normal livers and is extremely rare in cirrhosis. The authors present magnetic resonance imaging and histopathologic findings in a 57-year-old man with liver cirrhosis and hepatic adenomatosis. As the differentiation between HCA and hepatocellular carcinoma (HCC) can be difficult with imaging, we would like to highlight the importance of ancillary findings such as the presence of iron on MRI, which can be observed in HCA.

摘要

肝细胞腺瘤(HCA)是一种良性肝肿瘤,最常见于使用口服避孕药的女性。HCA在正常或近乎正常的肝脏中发生,在肝硬化中极为罕见。作者展示了一名57岁肝硬化和肝腺瘤病男性患者的磁共振成像和组织病理学结果。由于通过影像学鉴别HCA和肝细胞癌(HCC)可能存在困难,我们想强调辅助检查结果的重要性,比如MRI上铁的存在,这在HCA中可以观察到。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3af8/5597816/51dd4bd8c61a/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3af8/5597816/92a9c67d8473/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3af8/5597816/51dd4bd8c61a/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3af8/5597816/92a9c67d8473/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3af8/5597816/51dd4bd8c61a/gr2.jpg

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本文引用的文献

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Molecular Classification of Hepatocellular Adenoma Associates With Risk Factors, Bleeding, and Malignant Transformation.肝细胞腺瘤的分子分类与危险因素、出血和恶性转化相关。
Gastroenterology. 2017 Mar;152(4):880-894.e6. doi: 10.1053/j.gastro.2016.11.042. Epub 2016 Dec 7.
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Correlation of exon 3 β-catenin mutations with glutamine synthetase staining patterns in hepatocellular adenoma and hepatocellular carcinoma.
超声造影在肝细胞癌筛查与诊断中的应用:病例系列及文献综述
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Genotype-phenotype correlation of CTNNB1 mutations reveals different ß-catenin activity associated with liver tumor progression.CTNNB1 基因突变的表型-基因型相关性揭示了与肝肿瘤进展相关的不同 β-连环蛋白活性。
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Morphologic and Molecular Features of Hepatocellular Adenoma with Gadoxetic Acid-enhanced MR Imaging.钆塞酸增强磁共振成像在肝细胞腺瘤中的形态学和分子特征。
Radiology. 2015 Oct;277(1):104-13. doi: 10.1148/radiol.2015142366. Epub 2015 May 18.
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