McIntosh T K, Fernyak S, Faden A I
Department of Neurology, University of California, San Francisco.
NIDA Res Monogr. 1986;75:527-30.
The present study examined the role of endogenous opioid peptides in the pathophysiological sequelae of fluid percussion head injury in the cat. Two hours following injury, tissue concentrations of dynorphin-like immunoreactive material (ir-Dyn) were significantly elevated in specific brain regions where injury, as evidenced by histological examination, was most severe. Changes in ir-Dyn but not beta-endorphin-like immunoreactive material (ir-End) were significantly correlated with a fall in regional cerebral blood flow (CBF) that occurred 2 h following injury. Administration of the opiate antagonist WIN44,441-3 (with enhanced activity at kappa-receptors) stereospecifically increased cerebral blood flow to the injured regions.
本研究探讨了内源性阿片肽在猫液压冲击性颅脑损伤病理生理后遗症中的作用。损伤后两小时，强啡肽样免疫反应物质（ir-Dyn）的组织浓度在特定脑区显著升高，组织学检查显示这些脑区损伤最为严重。ir-Dyn而非β-内啡肽样免疫反应物质（ir-End）的变化与损伤后2小时出现的局部脑血流量（CBF）下降显著相关。给予阿片拮抗剂WIN44,441-3（对κ受体活性增强）可立体定向地增加损伤区域的脑血流量。
