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[脑肿瘤放射治疗后的认知缺陷]

[Cognitive deficits following brain tumor radiation therapy].

作者信息

Buthut M, Haussmann R, Seidlitz A, Krause M, Donix M

机构信息

Neurologische Klinik (Neustadt/Trachau), Städtisches Klinikum Dresden, Industriestr. 40, 01129, Dresden, Deutschland.

Klinik und Poliklinik für Psychiatrie und Psychotherapie, Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Fetscherstr. 74, 01307, Dresden, Deutschland.

出版信息

Nervenarzt. 2018 Apr;89(4):423-430. doi: 10.1007/s00115-017-0423-y.

DOI:10.1007/s00115-017-0423-y
PMID:28932944
Abstract

Brain radiation is an important treatment option for malignant and benign brain diseases. The possible acute or chronic impact of radiation therapy on cognitive performance is important for daily functioning and quality of life. A detailed evaluation of cognitive impairment is important in the context of how to control disease progression. The susceptibility of the hippocampus to radiation-induced neuronal damage and its important role in memory highlight that therapeutic strategies require precision medicine.

摘要

脑部放疗是治疗恶性和良性脑部疾病的重要选择。放射治疗对认知功能可能产生的急性或慢性影响,对于日常功能和生活质量至关重要。在如何控制疾病进展的背景下,对认知障碍进行详细评估很重要。海马体对辐射诱导的神经元损伤的易感性及其在记忆中的重要作用表明,治疗策略需要精准医学。

相似文献

1
[Cognitive deficits following brain tumor radiation therapy].[脑肿瘤放射治疗后的认知缺陷]
Nervenarzt. 2018 Apr;89(4):423-430. doi: 10.1007/s00115-017-0423-y.
2
Hippocampal dysfunctions caused by cranial irradiation: a review of the experimental evidence.颅脑照射引起的海马功能障碍:实验证据综述。
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A prospective evaluation of hippocampal radiation dose volume effects and memory deficits following cranial irradiation.颅脑照射后海马体辐射剂量体积效应与记忆缺陷的前瞻性评估。
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Neuroplastic Response After Radiation Therapy for Pediatric Brain Tumors: A Pilot Study.小儿脑肿瘤放疗后的神经可塑性反应:一项初步研究。
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本文引用的文献

1
Radiation Dose-Dependent Hippocampal Atrophy Detected With Longitudinal Volumetric Magnetic Resonance Imaging.通过纵向容积磁共振成像检测到的辐射剂量依赖性海马萎缩
Int J Radiat Oncol Biol Phys. 2017 Feb 1;97(2):263-269. doi: 10.1016/j.ijrobp.2016.10.035. Epub 2016 Oct 31.
2
Post-WBRT cognitive impairment and hippocampal neuronal depletion measured by in vivo metabolic MR spectroscopy: Results of prospective investigational study.体素内磁共振波谱测量 WBRT 后认知障碍和海马神经元缺失:前瞻性研究结果。
Radiother Oncol. 2017 Mar;122(3):373-379. doi: 10.1016/j.radonc.2016.12.013. Epub 2017 Jan 4.
3
Proton therapy - Present and future.
质子治疗——现状与未来。
Adv Drug Deliv Rev. 2017 Jan 15;109:26-44. doi: 10.1016/j.addr.2016.11.006. Epub 2016 Dec 3.
4
Postnatal irradiation-induced hippocampal neuropathology, cognitive impairment and aging.产后辐射诱导的海马神经病理学、认知障碍和衰老。
Brain Dev. 2017 Apr;39(4):277-293. doi: 10.1016/j.braindev.2016.11.001. Epub 2016 Nov 19.
5
Mechanisms of post-radiation injury: cerebral microinfarction not a significant factor.辐射后损伤的机制:脑微梗死并非重要因素。
J Neurooncol. 2017 Jan;131(2):277-281. doi: 10.1007/s11060-016-2291-x. Epub 2016 Oct 18.
6
Cognitive, behaviour, and academic functioning in adolescent and young adult survivors of childhood acute lymphoblastic leukaemia: a report from the Childhood Cancer Survivor Study.儿童急性淋巴细胞白血病青少年及青年幸存者的认知、行为和学业功能:来自儿童癌症幸存者研究的报告
Lancet Psychiatry. 2016 Oct;3(10):965-972. doi: 10.1016/S2215-0366(16)30283-8. Epub 2016 Sep 14.
7
Effect of Radiosurgery Alone vs Radiosurgery With Whole Brain Radiation Therapy on Cognitive Function in Patients With 1 to 3 Brain Metastases: A Randomized Clinical Trial.单纯放射外科治疗与放射外科联合全脑放射治疗对1至3个脑转移瘤患者认知功能的影响:一项随机临床试验。
JAMA. 2016 Jul 26;316(4):401-409. doi: 10.1001/jama.2016.9839.
8
Dosimetric advantages of proton therapy over conventional radiotherapy with photons in young patients and adults with low-grade glioma.质子治疗相对于传统光子放疗在年轻患者和低级别胶质瘤成年患者中的剂量学优势。
Strahlenther Onkol. 2016 Nov;192(11):759-769. doi: 10.1007/s00066-016-1005-9. Epub 2016 Jun 30.
9
Neurocognitive profile in major depressive disorders: relationship to symptom level and subjective memory complaints.重度抑郁症的神经认知特征:与症状水平及主观记忆主诉的关系
BMC Psychiatry. 2016 Apr 19;16:108. doi: 10.1186/s12888-016-0815-8.
10
Population Studies of Association Between Lithium and Risk of Neurodegenerative Disorders.锂与神经退行性疾病风险之间关联的人群研究
Curr Alzheimer Res. 2016;13(8):873-8. doi: 10.2174/1567205013666160219112957.